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10.1038/nmicrobiol.2016.251

http://scihub22266oqcxt.onion/10.1038/nmicrobiol.2016.251
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C5508108!5508108!28067906
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suck abstract from ncbi


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pmid28067906      Nat+Microbiol 2017 ; 2 (ä): 16251
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  • Prophage-mediated defense against viral attack and viral counter-defense #MMPMID28067906
  • Dedrick RM; Jacobs-Sera D; Guerrero Bustamante CA; Garlena RA; Mavrich TN; Pope WH; Reyes JCC; Russell DA; Adair T; Alvey R; Bonilla JA; Bricker JS; Brown BR; Byrnes D; Cresawn SG; Davis WB; Dickson LA; Edgington NP; Findley AM; Golebiewska U; Grose JH; Hayes CF; Hughes LE; Hutchison KW; Isern S; Johnson AA; Kenna MA; Klyczek KK; Mageeney CM; Michael SF; Molloy SD; Montgomery MT; Neitzel J; Page ST; Pizzorno MC; Poxleitner MK; Rinehart CA; Robinson CJ; Rubin MR; Teyim JN; Vazquez E; Ware VC; Washington J; Hatfull GF
  • Nat Microbiol 2017[Jan]; 2 (ä): 16251 PMID28067906show ga
  • Temperate phages are common and prophages are abundant residents of sequenced bacterial genomes. Mycobacteriophages are viruses infecting mycobacterial hosts including Mycobacterium tuberculosis and Mycobacterium smegmatis, encompass substantial genetic diversity, and are commonly temperate. Characterization of ten Cluster N temperate mycobacteriophages reveals at least five distinct prophage-expressed viral defense systems that interfere with infection of lytic and temperate phages that are either closely-related (homotypic defense) or unrelated (heterotypic defense). Target specificity is unpredictable, ranging from a single target phage to one-third of those tested. The defense systems include a single-subunit restriction system, a heterotypic exclusion system, and a predicted (p)ppGpp synthetase, which blocks lytic phage growth, promotes bacterial survival, and enables efficient lysogeny. The predicted (p)ppGpp synthetase coded by the Phrann prophage defends against phage Tweety infection, but Tweety codes for a tetrapeptide repeat protein, gp54, that acts as a highly effective counter-defense system. Prophage-mediated viral defense offers an efficient mechanism for bacterial success in host-virus dynamics, and counter-defense promotes phage co-evolution.
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