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10.1038/s41598-017-05467-x http://scihub22266oqcxt.onion/10.1038/s41598-017-05467-x C5507932!5507932 !28701767     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28701767 &cmd=llinks): Failed to open stream: HTTP request failed! 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Actomyosin and vimentin cytoskeletal networks regulate nuclear shape, mechanics and chromatin organization |pdf=|usr=}}{{28701767 }} gab.com Text Actomyosin and vimentin cytoskeletal networks regulate nuclear shape, mechanics and chromatin organization JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28701767 #FOAvip The regulation of nuclear state by the cytoskeleton is an important part of cellular function. Actomyosin stress fibres, microtubules and intermediate filaments have distinct and complementary roles in integrating the nucleus into its environment and influencing its mechanical state. However, the interconnectedness of cytoskeletal networks makes it difficult to dissect their individual effects on the nucleus. We use simple image analysis approaches to characterize nuclear state, estimating nuclear volume, Poisson's ratio, apparent elastic modulus and chromatin condensation. By combining them with cytoskeletal quantification, we assess how cytoskeletal organization regulates nuclear state. We report for a number of cell types that nuclei display auxetic properties. Furthermore, stress fibres and intermediate filaments modulate the mechanical properties of the nucleus and also chromatin condensation. Conversely, nuclear volume and its gross morphology are regulated by intracellular outward pulling forces exerted by myosin. The modulation exerted by the cytoskeleton onto the nucleus results in changes that are of similar magnitude to those observed when the nucleus is altered intrinsically, inducing chromatin decondensation or cell differentiation. Our approach allows pinpointing the contribution of distinct cytoskeletal proteins to nuclear mechanical state in physio- and pathological conditions, furthering our understanding of a key aspect of cellular behaviour. Twit Text FOAVip Actomyosin and vimentin cytoskeletal networks regulate nuclear shape, mechanics and chromatin organization ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28701767 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28701767 #FOAvip English Wikipedia <ref>{{Cite pmid|28701767 }}</ref> Actomyosin and vimentin cytoskeletal networks regulate nuclear shape, mechanics and chromatin organization #MMPMID28701767 Keeling MC ; Flores LR ; Dodhy AH ; Murray ER ; Gavara N Sci Rep 2017[Jul]; 7 (1 ): 5219 PMID28701767 show ga The regulation of nuclear state by the cytoskeleton is an important part of cellular function. Actomyosin stress fibres, microtubules and intermediate filaments have distinct and complementary roles in integrating the nucleus into its environment and influencing its mechanical state. However, the interconnectedness of cytoskeletal networks makes it difficult to dissect their individual effects on the nucleus. We use simple image analysis approaches to characterize nuclear state, estimating nuclear volume, Poisson's ratio, apparent elastic modulus and chromatin condensation. By combining them with cytoskeletal quantification, we assess how cytoskeletal organization regulates nuclear state. We report for a number of cell types that nuclei display auxetic properties. Furthermore, stress fibres and intermediate filaments modulate the mechanical properties of the nucleus and also chromatin condensation. Conversely, nuclear volume and its gross morphology are regulated by intracellular outward pulling forces exerted by myosin. The modulation exerted by the cytoskeleton onto the nucleus results in changes that are of similar magnitude to those observed when the nucleus is altered intrinsically, inducing chromatin decondensation or cell differentiation. Our approach allows pinpointing the contribution of distinct cytoskeletal proteins to nuclear mechanical state in physio- and pathological conditions, furthering our understanding of a key aspect of cellular behaviour. |*Stress, Mechanical [MESH] |Actomyosin/*metabolism [MESH] |Animals [MESH] |Bone Marrow/growth & development [MESH] |Cell Differentiation [MESH] |Cell Nucleus/*physiology [MESH] |Cells, Cultured [MESH] |Chromatin/*physiology [MESH] |Cytoskeleton/*physiology [MESH] |Human Umbilical Vein Endothelial Cells [MESH] |Humans [MESH] |Mesenchymal Stem Cells/cytology/*physiology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Microtubules/physiology [MESH] |Pancreatic Stellate Cells/cytology/*physiology [MESH]Actomyosin and vimentin cytoskeletal networks regulate nuclear shape, (epmc).pdf DeepDyve Pubget Overpricing