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10.4174/astr.2017.93.1.11

http://scihub22266oqcxt.onion/10.4174/astr.2017.93.1.11
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C5507786!5507786!28706886
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suck abstract from ncbi


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pmid28706886      Ann+Surg+Treat+Res 2017 ; 93 (1): 11-7
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  • The effects of indoxyl sulfate-induced endothelial microparticles on neointimal hyperplasia formation in an ex vivo model #MMPMID28706886
  • Ryu JH; Park H; Kim SJ
  • Ann Surg Treat Res 2017[Jul]; 93 (1): 11-7 PMID28706886show ga
  • Purpose: Neointimal hyperplasia (NH) is considered to be one of the main causes of vascular access occlusion in patients receiving hemodialysis. Endothelial injury and TGF-?-mediated proliferation of vascular smooth muscle cells (VSMCs) induce NH. Endothelial microparticles (EMPs) are also increased by endothelial injury. We aimed to investigate the effects of EMPs and TGF-? expression on VSMC proliferation and their contributions to NH formation in an ex vivo model. Methods: EMPs were collected from the culture media of human umbilical vein endothelial cells treated with indoxyl sulfate (IS, 250 µg/mL) after ultracentrifugation at 100,000 × g. Porcine internal jugular veins were isolated and treated with EMPs (2 × 106 /mL) or left untreated for 12 days and subsequently compared with TGF-? (10 ng/mL)-treated venous tissue. Intima-media thickness and NH area were assessed using a digital program. Masson's trichrome staining and immunohistochemistry (IHC) analysis for ?-smooth muscle actin, phosphorylated Akt, ERK1/2, p38 mitogen-activated protein kinase (MAPK), and Smad3 were performed on each vein sample. Results: NH and VSMC proliferation developed to a significantly greater degree in EMP-treated veins compared to controls, with similar patterns seen in TGF-?-stimulated samples. IHC analysis demonstrated that EMPs markedly increased phosphorylation of Akt, ERK1/2, p38 MAPK, and Smad3 in areas of venous NH formation. Conclusion: Our results showed that IS-induced EMPs provoked massive VSMC proliferation and NH formation via activation of the TGF-? signaling pathways. Further investigation is needed to elucidate the precise mechanism of EMP activity on vascular access stenosis in vivo.
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