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10.1111/head.13121

http://scihub22266oqcxt.onion/10.1111/head.13121
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C5507708!5507708!28627714
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suck abstract from ncbi


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pmid28627714      Headache 2017 ; 57 (7): 1051-64
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  • Migraine sub-classification via a data-driven automated approach using multimodality factor mixture modeling of brain structure measurements #MMPMID28627714
  • Schwedt TJ; Si B; Li J; Wu T; Chong CD
  • Headache 2017[Jul]; 57 (7): 1051-64 PMID28627714show ga
  • Background: The current sub-classification of migraine is according to headache frequency and aura status. The variability in migraine symptoms, disease course, and response to treatment suggest the presence of additional heterogeneity or subclasses within migraine. Objective: The study objective was to sub-classify migraine via a data-driven approach, identifying latent factors by jointly exploiting multiple sets of brain structural features obtained via magnetic resonance imaging (MRI). Methods: Migraineurs (n=66) and healthy controls (n=54) had brain MRI measurements of cortical thickness, cortical surface area, and volumes for 68 regions. A multi-modality factor mixture model was used to sub-classify MRIs and to determine the brain structural factors that most contributed to the sub-classification. Clinical characteristics of subjects in each sub-group were compared. Results: Automated MRI classification divided the subjects into two sub-groups. Migraineurs in sub-group #1 had more severe allodynia symptoms during migraines (6.1 +/? 5.3 vs. 3.6 +/?3.2, p = .03), more years with migraine (19.2 +/? 11.3 years vs. 13 +/? 8.3 years, p = .01), and higher Migraine Disability Assessment (MIDAS) scores (25 +/? 22.9 vs. 15.7 +/? 12.2, p = .04). There were not differences in headache frequency or migraine aura status between the two sub-groups. Conclusions: Data-driven sub-classification of brain MRIs based upon structural measurements identified two sub-groups. Amongst migraineurs, the sub-groups differed in allodynia symptom severity, years with migraine, and migraine-related disability. Since allodynia is associated with this imaging-based sub-classification of migraine and prior publications suggest that allodynia impacts migraine treatment response and disease prognosis, future migraine diagnostic criteria could consider allodynia when defining migraine sub-groups.
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