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10.1371/journal.pone.0180642 http://scihub22266oqcxt.onion/10.1371/journal.pone.0180642 C5507516!5507516 !28704412     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28704412 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2017 ; 12 (7 ): e0180642 Nephropedia Template TP {{tp|p=28704412 |t=2017. Synthetic PreImplantation Factor (PIF) prevents fetal loss by modulating LPS induced inflammatory response |pdf=|usr=}}{{28704412 }} gab.com Text Synthetic PreImplantation Factor (PIF) prevents fetal loss by modulating LPS induced inflammatory response JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28704412 #FOAvip Maternal control of inflammation is essential during pregnancy and an exaggerated response is one of the underlying causes of fetal loss. Inflammatory response is mediated by multiple factors and Toll-like receptors (TLRs) are central. Activation of TLRs results in NALP-3 mediated assembly of apoptosis-associated speck-like protein containing a CARD (ASC) and caspase-1 into the inflammasome and production of pro-inflammatory cytokines IL-1? and IL-18. Given that preventing measures are lacking, we investigated PreImplantation Factor (PIF) as therapeutic option as PIF modulates Inflammation in pregnancy. Additionally, synthetic PIF (PIF analog) protects against multiple immune disorders. We used a LPS induced murine model of fetal loss and synthetic PIF reduced this fetal loss and increased the embryo weight significantly. We detected increased PIF expression in the placentae after LPS insult. The LPS induced serum and placenta cytokines were abolished by synthetic PIF treatment and importantly synthetic PIF modulated key members of inflammasome complex NALP-3, ASC, and caspase-1 as well. In conclusion our results indicate that synthetic PIF protects against LPS induced fetal loss, likely through modulation of inflammatory response especially the inflammasome complex. Given that synthetic PIF is currently tested in autoimmune diseases of non-pregnant subjects (clinicaltrials.gov, NCT02239562), therapeutic approach during pregnancy can be envisioned. Twit Text FOAVip Synthetic PreImplantation Factor (PIF) prevents fetal loss by modulating LPS induced inflammatory response ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28704412 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28704412 #FOAvip English Wikipedia <ref>{{Cite pmid|28704412 }}</ref> Synthetic PreImplantation Factor (PIF) prevents fetal loss by modulating LPS induced inflammatory response #MMPMID28704412 Di Simone N ; Di Nicuolo F ; Marana R ; Castellani R ; Ria F ; Veglia M ; Scambia G ; Surbek D ; Barnea E ; Mueller M PLoS One 2017[]; 12 (7 ): e0180642 PMID28704412 show ga Maternal control of inflammation is essential during pregnancy and an exaggerated response is one of the underlying causes of fetal loss. Inflammatory response is mediated by multiple factors and Toll-like receptors (TLRs) are central. Activation of TLRs results in NALP-3 mediated assembly of apoptosis-associated speck-like protein containing a CARD (ASC) and caspase-1 into the inflammasome and production of pro-inflammatory cytokines IL-1? and IL-18. Given that preventing measures are lacking, we investigated PreImplantation Factor (PIF) as therapeutic option as PIF modulates Inflammation in pregnancy. Additionally, synthetic PIF (PIF analog) protects against multiple immune disorders. We used a LPS induced murine model of fetal loss and synthetic PIF reduced this fetal loss and increased the embryo weight significantly. We detected increased PIF expression in the placentae after LPS insult. The LPS induced serum and placenta cytokines were abolished by synthetic PIF treatment and importantly synthetic PIF modulated key members of inflammasome complex NALP-3, ASC, and caspase-1 as well. In conclusion our results indicate that synthetic PIF protects against LPS induced fetal loss, likely through modulation of inflammatory response especially the inflammasome complex. Given that synthetic PIF is currently tested in autoimmune diseases of non-pregnant subjects (clinicaltrials.gov, NCT02239562), therapeutic approach during pregnancy can be envisioned. |Abortion, Spontaneous/*drug therapy/etiology/prevention & control [MESH] |Animals [MESH] |Anti-Inflammatory Agents/pharmacology/*therapeutic use [MESH] |Apoptosis Regulatory Proteins/genetics/metabolism [MESH] |CARD Signaling Adaptor Proteins [MESH] |Caspase 1/genetics/metabolism [MESH] |Cytokines/*blood [MESH] |Female [MESH] |Fetal Weight/drug effects [MESH] |Immune System Diseases/prevention & control [MESH] |Inflammasomes/metabolism [MESH] |Inflammation/etiology [MESH] |Lipopolysaccharides/toxicity [MESH] |Mice [MESH] |NLR Family, Pyrin Domain-Containing 3 Protein/genetics/metabolism [MESH] |Peptides/genetics/metabolism/pharmacology/*therapeutic use [MESH] |Placenta/metabolism [MESH]Synthetic PreImplantation Factor (PIF) prevents fetal loss by modulati(epmc).pdf DeepDyve Pubget Overpricing