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10.1371/journal.pone.0180853 http://scihub22266oqcxt.onion/10.1371/journal.pone.0180853 C5507280!5507280 !28700632     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28700632 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2017 ; 12 (7 ): e0180853 Nephropedia Template TP {{tp|p=28700632 |t=2017. Inflammation dependent mTORC1 signaling interferes with the switch from keratinocyte proliferation to differentiation |pdf=|usr=}}{{28700632 }} gab.com Text Inflammation dependent mTORC1 signaling interferes with the switch from keratinocyte proliferation to differentiation JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28700632 #FOAvip Psoriasis is a frequent and often severe inflammatory skin disease, characterized by altered epidermal homeostasis. Since we found previously that Akt/mTOR signaling is hyperactivated in psoriatic skin, we aimed at elucidating the role of aberrant mTORC1 signaling in this disease. We found that under healthy conditions mTOR signaling was shut off when keratinocytes switch from proliferation to terminal differentiation. Inflammatory cytokines (IL-1?, IL-17A, TNF-?) induced aberrant mTOR activity which led to enhanced proliferation and reduced expression of differentiation markers. Conversely, regular differentiation could be restored if mTORC1 signaling was blocked. In mice, activation of mTOR through the agonist MHY1485 also led to aberrant epidermal organization and involucrin distribution. In summary, these results not only identify mTORC1 as an important signal integrator pivotal for the cells fate to either proliferate or differentiate, but emphasize the role of inflammation-dependent mTOR activation as a psoriatic pathomechanism. Twit Text FOAVip Inflammation dependent mTORC1 signaling interferes with the switch from keratinocyte proliferation to differentiation ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28700632 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28700632 #FOAvip English Wikipedia <ref>{{Cite pmid|28700632 }}</ref> Inflammation dependent mTORC1 signaling interferes with the switch from keratinocyte proliferation to differentiation #MMPMID28700632 Buerger C ; Shirsath N ; Lang V ; Berard A ; Diehl S ; Kaufmann R ; Boehncke WH ; Wolf P PLoS One 2017[]; 12 (7 ): e0180853 PMID28700632 show ga Psoriasis is a frequent and often severe inflammatory skin disease, characterized by altered epidermal homeostasis. Since we found previously that Akt/mTOR signaling is hyperactivated in psoriatic skin, we aimed at elucidating the role of aberrant mTORC1 signaling in this disease. We found that under healthy conditions mTOR signaling was shut off when keratinocytes switch from proliferation to terminal differentiation. Inflammatory cytokines (IL-1?, IL-17A, TNF-?) induced aberrant mTOR activity which led to enhanced proliferation and reduced expression of differentiation markers. Conversely, regular differentiation could be restored if mTORC1 signaling was blocked. In mice, activation of mTOR through the agonist MHY1485 also led to aberrant epidermal organization and involucrin distribution. In summary, these results not only identify mTORC1 as an important signal integrator pivotal for the cells fate to either proliferate or differentiate, but emphasize the role of inflammation-dependent mTOR activation as a psoriatic pathomechanism. |Adolescent [MESH] |Adult [MESH] |Aged [MESH] |Animals [MESH] |Cell Differentiation/genetics/physiology [MESH] |Cell Line [MESH] |Cell Proliferation/genetics/physiology [MESH] |Female [MESH] |Humans [MESH] |Immunoassay [MESH] |Immunohistochemistry [MESH] |Keratinocytes/*metabolism/physiology [MESH] |Male [MESH] |Mechanistic Target of Rapamycin Complex 1 [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Middle Aged [MESH] |Multiprotein Complexes/genetics/*metabolism [MESH] |RNA, Small Interfering/genetics [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |Signal Transduction/genetics/physiology [MESH] |TOR Serine-Threonine Kinases/genetics/*metabolism [MESH]Inflammation dependent mTORC1 signaling interferes with the switch fro(epmc).pdf DeepDyve Pubget Overpricing