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2017 ; 63
(7
): 512-520
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Community-associated methicillin-resistant Staphylococcus aureus infection:
Literature review and clinical update
#MMPMID28701438
Loewen K
; Schreiber Y
; Kirlew M
; Bocking N
; Kelly L
Can Fam Physician
2017[Jul]; 63
(7
): 512-520
PMID28701438
show ga
OBJECTIVE: To provide information on the prevalence and treatment of
methicillin-resistant Staphylococcus aureus (MRSA) infections and the distinction
between community-associated MRSA and health care-associated MRSA. QUALITY OF
EVIDENCE: The MEDLINE and EMBASE databases were searched from 2005 to 2016.
Epidemiologic studies were summarized and the relevant treatment literature was
based on level I evidence. MAIN MESSAGE: The incidence of community-associated
MRSA infection is rising. Certain populations, including indigenous Canadians and
homeless populations, are particularly affected. Community-associated MRSA can be
distinguished from health care-associated MRSA based on genetic, epidemiologic,
or microbiological profiles. It retains susceptibility to some oral agents
including trimethoprim-sulfamethoxazole, clindamycin, and tetracyclines.
Community-associated MRSA typically presents as purulent skin and soft tissue
infection, but invasive infection occurs and can lead to severe, complicated
disease. Treatment choices and the need for empiric MRSA coverage are influenced
by the type and severity of infection. CONCLUSION: Community-associated MRSA is a
common cause of skin and soft tissue infections and might be common in
populations where overcrowding and limited access to clean water exist.