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10.1126/science.aah5298 http://scihub22266oqcxt.onion/10.1126/science.aah5298 C5506690!5506690 !28386004     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28386004 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Science 2017 ; 356 (6333 ): 44-50 Nephropedia Template TP {{tp|p=28386004 |t=2017. Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease |pdf=|usr=}}{{28386004 }} gab.com Text Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=28386004 #FOAvip Viral infections have been proposed to elicit pathological processes leading to the initiation of T helper 1 (T(H)1) immunity against dietary gluten and celiac disease (CeD). To test this hypothesis and gain insights into mechanisms underlying virus-induced loss of tolerance to dietary antigens, we developed a viral infection model that makes use of two reovirus strains that infect the intestine but differ in their immunopathological outcomes. Reovirus is an avirulent pathogen that elicits protective immunity, but we discovered that it can nonetheless disrupt intestinal immune homeostasis at inductive and effector sites of oral tolerance by suppressing peripheral regulatory T cell (pT(reg)) conversion and promoting T(H)1 immunity to dietary antigen. Initiation of T(H)1 immunity to dietary antigen was dependent on interferon regulatory factor 1 and dissociated from suppression of pT(reg) conversion, which was mediated by type-1 interferon. Last, our study in humans supports a role for infection with reovirus, a seemingly innocuous virus, in triggering the development of CeD. Twit Text FOAVip Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease ????Science http://www.kidney.de/pget.php?&tw=1&pmid=28386004 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28386004 #FOAvip English Wikipedia <ref>{{Cite pmid|28386004 }}</ref> Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease #MMPMID28386004 Bouziat R ; Hinterleitner R ; Brown JJ ; Stencel-Baerenwald JE ; Ikizler M ; Mayassi T ; Meisel M ; Kim SM ; Discepolo V ; Pruijssers AJ ; Ernest JD ; Iskarpatyoti JA ; Costes LM ; Lawrence I ; Palanski BA ; Varma M ; Zurenski MA ; Khomandiak S ; McAllister N ; Aravamudhan P ; Boehme KW ; Hu F ; Samsom JN ; Reinecker HC ; Kupfer SS ; Guandalini S ; Semrad CE ; Abadie V ; Khosla C ; Barreiro LB ; Xavier RJ ; Ng A ; Dermody TS ; Jabri B Science 2017[Apr]; 356 (6333 ): 44-50 PMID28386004 show ga Viral infections have been proposed to elicit pathological processes leading to the initiation of T helper 1 (T(H)1) immunity against dietary gluten and celiac disease (CeD). To test this hypothesis and gain insights into mechanisms underlying virus-induced loss of tolerance to dietary antigens, we developed a viral infection model that makes use of two reovirus strains that infect the intestine but differ in their immunopathological outcomes. Reovirus is an avirulent pathogen that elicits protective immunity, but we discovered that it can nonetheless disrupt intestinal immune homeostasis at inductive and effector sites of oral tolerance by suppressing peripheral regulatory T cell (pT(reg)) conversion and promoting T(H)1 immunity to dietary antigen. Initiation of T(H)1 immunity to dietary antigen was dependent on interferon regulatory factor 1 and dissociated from suppression of pT(reg) conversion, which was mediated by type-1 interferon. Last, our study in humans supports a role for infection with reovirus, a seemingly innocuous virus, in triggering the development of CeD. |Animals [MESH] |Antigens/*immunology [MESH] |Celiac Disease/*immunology/*virology [MESH] |Diet/adverse effects [MESH] |Disease Models, Animal [MESH] |Genetic Engineering [MESH] |Glutens/*immunology [MESH] |Humans [MESH] |Immune Tolerance [MESH] |Inflammation/immunology/*virology [MESH] |Interferon Regulatory Factor-1/genetics/immunology [MESH] |Interferon Type I/genetics/immunology [MESH] |Intestines/immunology/pathology/virology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH] |Receptor, Interferon alpha-beta/genetics [MESH] |Reoviridae Infections/*complications/*immunology [MESH] |Reoviridae/genetics [MESH]Reovirus infection triggers inflammatory responses to dietary antigens(epmc).pdf DeepDyve Pubget Overpricing