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10.14814/phy2.13335 http://scihub22266oqcxt.onion/10.14814/phy2.13335 C5506523!5506523 !28676554     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28676554 &cmd=llinks): Failed to open stream: HTTP request failed! 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Diabetic rats present higher urinary loss of proteins and lower renal expression of megalin, cubilin, ClC-5, and CFTR |pdf=|usr=}}{{28676554 }} gab.com Text Diabetic rats present higher urinary loss of proteins and lower renal expression of megalin, cubilin, ClC-5, and CFTR JO: Physiol Rep http://www.kidney.de/pget.php?&tw=1&pmid=28676554 #FOAvip Diabetic nephropathy (DN) occurs in around 40% of those with diabetes. Proteinuria is the main characteristic of DN and develops as a result of increased permeability of the glomerulus capillary wall and/or decreased proximal tubule endocytosis. The goal of this work was to evaluate renal function and the expression of megalin, cubilin, CFTR (cystic fibrosis transmembrane conductance regulator), and ClC-5 in the proximal tubule and renal cortex of rats with type 1 diabetes. Male Wistar rats were randomly assigned to control (CTRL) and diabetic (DM) groups for 4 weeks. Renal function was assessed in 24-h urine sample by calculating clearance and fractional excretion of solutes. The RNA and protein contents of ClC-5, CFTR, megalin, and cubilin were determined in the renal proximal tubule and cortex using real-time polymerase chain reaction and western blotting techniques, respectively. The results showed higher creatinine clearance and higher urinary excretion of proteins, albumin, and transferrin in the DM group than in the CTRL group. Furthermore, the renal cortex and proximal tubule of diabetic animals showed downregulation of megalin, cubilin, ClC-5, and CFTR, critical components of the endocytic apparatus. These data suggest dysfunction in proximal tubule low-molecular-weight endocytosis and protein glomerulus filtration in the kidney of diabetic rats. Twit Text FOAVip Diabetic rats present higher urinary loss of proteins and lower renal expression of megalin, cubilin, ClC-5, and CFTR ????Physiol Rep http://www.kidney.de/pget.php?&tw=1&pmid=28676554 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28676554 #FOAvip English Wikipedia <ref>{{Cite pmid|28676554 }}</ref> Diabetic rats present higher urinary loss of proteins and lower renal expression of megalin, cubilin, ClC-5, and CFTR #MMPMID28676554 Figueira MF ; Castiglione RC ; de Lemos Barbosa CM ; Ornellas FM ; da Silva Feltran G ; Morales MM ; da Fonseca RN ; de Souza-Menezes J Physiol Rep 2017[Jul]; 5 (13 ): ä PMID28676554 show ga Diabetic nephropathy (DN) occurs in around 40% of those with diabetes. Proteinuria is the main characteristic of DN and develops as a result of increased permeability of the glomerulus capillary wall and/or decreased proximal tubule endocytosis. The goal of this work was to evaluate renal function and the expression of megalin, cubilin, CFTR (cystic fibrosis transmembrane conductance regulator), and ClC-5 in the proximal tubule and renal cortex of rats with type 1 diabetes. Male Wistar rats were randomly assigned to control (CTRL) and diabetic (DM) groups for 4 weeks. Renal function was assessed in 24-h urine sample by calculating clearance and fractional excretion of solutes. The RNA and protein contents of ClC-5, CFTR, megalin, and cubilin were determined in the renal proximal tubule and cortex using real-time polymerase chain reaction and western blotting techniques, respectively. The results showed higher creatinine clearance and higher urinary excretion of proteins, albumin, and transferrin in the DM group than in the CTRL group. Furthermore, the renal cortex and proximal tubule of diabetic animals showed downregulation of megalin, cubilin, ClC-5, and CFTR, critical components of the endocytic apparatus. These data suggest dysfunction in proximal tubule low-molecular-weight endocytosis and protein glomerulus filtration in the kidney of diabetic rats. |Albuminuria/*metabolism/physiopathology/urine [MESH] |Animals [MESH] |Chloride Channels/genetics/metabolism [MESH] |Creatinine/urine [MESH] |Cystic Fibrosis Transmembrane Conductance Regulator/genetics/metabolism [MESH] |Diabetic Nephropathies/*metabolism/physiopathology/urine [MESH] |Glomerular Filtration Rate [MESH] |Kidney Tubules, Proximal/*metabolism/physiopathology [MESH] |Low Density Lipoprotein Receptor-Related Protein-2/genetics/metabolism [MESH] |Male [MESH] |RNA, Messenger/genetics/metabolism [MESH] |Rats [MESH] |Rats, Wistar [MESH] |Receptors, Cell Surface/genetics/metabolism [MESH]Diabetic rats present higher urinary loss of proteins and lower renal (epmc).pdf DeepDyve Pubget Overpricing