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10.1038/s41598-017-05052-2 http://scihub22266oqcxt.onion/10.1038/s41598-017-05052-2 C5506014!5506014 !28698627     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28698627 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 5040 Nephropedia Template TP {{tp|p=28698627 |t=2017. The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells |pdf=|usr=}}{{28698627 }} gab.com Text The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28698627 #FOAvip Mitochondrial integrity is critical for the regulation of cellular energy and apoptosis. Metformin is an energy disruptor targeting complex I of the respiratory chain. We demonstrate that metformin induces endoplasmic reticulum (ER) stress, calcium release from the ER and subsequent uptake of calcium into the mitochondria, thus leading to mitochondrial swelling. Metformin triggers the disorganization of the cristae and inner mitochondrial membrane in several cancer cells and tumors. Mechanistically, these alterations were found to be due to calcium entry into the mitochondria, because the swelling induced by metformin was reversed by the inhibition of mitochondrial calcium uniporter (MCU). We also demonstrated that metformin inhibits the opening of mPTP and induces mitochondrial biogenesis. Altogether, the inhibition of mPTP and the increase in mitochondrial biogenesis may account for the poor pro-apoptotic effect of metformin in cancer cells. Twit Text FOAVip The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28698627 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28698627 #FOAvip English Wikipedia <ref>{{Cite pmid|28698627 }}</ref> The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells #MMPMID28698627 Loubiere C ; Clavel S ; Gilleron J ; Harisseh R ; Fauconnier J ; Ben-Sahra I ; Kaminski L ; Laurent K ; Herkenne S ; Lacas-Gervais S ; Ambrosetti D ; Alcor D ; Rocchi S ; Cormont M ; Michiels JF ; Mari B ; Mazure NM ; Scorrano L ; Lacampagne A ; Gharib A ; Tanti JF ; Bost F Sci Rep 2017[Jul]; 7 (1 ): 5040 PMID28698627 show ga Mitochondrial integrity is critical for the regulation of cellular energy and apoptosis. Metformin is an energy disruptor targeting complex I of the respiratory chain. We demonstrate that metformin induces endoplasmic reticulum (ER) stress, calcium release from the ER and subsequent uptake of calcium into the mitochondria, thus leading to mitochondrial swelling. Metformin triggers the disorganization of the cristae and inner mitochondrial membrane in several cancer cells and tumors. Mechanistically, these alterations were found to be due to calcium entry into the mitochondria, because the swelling induced by metformin was reversed by the inhibition of mitochondrial calcium uniporter (MCU). We also demonstrated that metformin inhibits the opening of mPTP and induces mitochondrial biogenesis. Altogether, the inhibition of mPTP and the increase in mitochondrial biogenesis may account for the poor pro-apoptotic effect of metformin in cancer cells. |Animals [MESH] |Calcium/*metabolism [MESH] |Cell Line, Tumor [MESH] |Endoplasmic Reticulum Stress/drug effects [MESH] |Endoplasmic Reticulum/drug effects/metabolism [MESH] |Energy Metabolism/*drug effects [MESH] |Humans [MESH] |Metformin/*pharmacology [MESH] |Mice [MESH] |Mitochondria/drug effects/*metabolism/ultrastructure [MESH] |Mitochondrial Membrane Transport Proteins/metabolism [MESH] |Mitochondrial Permeability Transition Pore [MESH] |Mitochondrial Swelling/drug effects [MESH] |Models, Biological [MESH]The energy disruptor metformin targets mitochondrial integrity via mod(epmc).pdf DeepDyve Pubget Overpricing