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10.1038/s41598-017-03915-2 http://scihub22266oqcxt.onion/10.1038/s41598-017-03915-2 C5506002!5506002 !28698626     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28698626 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28698626 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 5088 Nephropedia Template TP {{tp|p=28698626 |t=2017. A genome-wide association study suggests the HLA Class II region as the major susceptibility locus for IgA vasculitis |pdf=|usr=}}{{28698626 }} gab.com Text A genome-wide association study suggests the HLA Class II region as the major susceptibility locus for IgA vasculitis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28698626 #FOAvip The genetic component of Immunoglobulin-A (IgA) vasculitis is still far to be elucidated. To increase the current knowledge on the genetic component of this vasculitis we performed the first genome-wide association study (GWAS) on this condition. 308 IgA vasculitis patients and 1,018 healthy controls from Spain were genotyped by Illumina HumanCore BeadChips. Imputation of GWAS data was performed using the 1000 Genomes Project Phase III dataset as reference panel. After quality control filters and GWAS imputation, 285 patients and 1,006 controls remained in the datasets and were included in further analysis. Additionally, the human leukocyte antigen (HLA) region was comprehensively studied by imputing classical alleles and polymorphic amino acid positions. A linkage disequilibrium block of polymorphisms located in the HLA class II region surpassed the genome-wide level of significance (OR?=?0.56, 95% CI?=?0.46-0.68). Although no polymorphic amino acid positions were associated at the genome-wide level of significance, P-values of potential relevance were observed for the positions 13 and 11 of HLA-DRB1 (P?=?6.67E-05, P?=?1.88E-05, respectively). Outside the HLA, potential associations were detected, but none of them were close to the statistical significance. In conclusion, our study suggests that IgA vasculitis is an archetypal HLA class II disease. Twit Text FOAVip A genome-wide association study suggests the HLA Class II region as the major susceptibility locus for IgA vasculitis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28698626 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28698626 #FOAvip English Wikipedia <ref>{{Cite pmid|28698626 }}</ref> A genome-wide association study suggests the HLA Class II region as the major susceptibility locus for IgA vasculitis #MMPMID28698626 López-Mejías R ; Carmona FD ; Castañeda S ; Genre F ; Remuzgo-Martínez S ; Sevilla-Perez B ; Ortego-Centeno N ; Llorca J ; Ubilla B ; Mijares V ; Pina T ; Miranda-Filloy JA ; Navas Parejo A ; de Argila D ; Aragües M ; Rubio E ; Luque ML ; Blanco-Madrigal JM ; Galíndez-Aguirregoikoa E ; Jayne D ; Blanco R ; Martín J ; González-Gay MA Sci Rep 2017[Jul]; 7 (1 ): 5088 PMID28698626 show ga The genetic component of Immunoglobulin-A (IgA) vasculitis is still far to be elucidated. To increase the current knowledge on the genetic component of this vasculitis we performed the first genome-wide association study (GWAS) on this condition. 308 IgA vasculitis patients and 1,018 healthy controls from Spain were genotyped by Illumina HumanCore BeadChips. Imputation of GWAS data was performed using the 1000 Genomes Project Phase III dataset as reference panel. After quality control filters and GWAS imputation, 285 patients and 1,006 controls remained in the datasets and were included in further analysis. Additionally, the human leukocyte antigen (HLA) region was comprehensively studied by imputing classical alleles and polymorphic amino acid positions. A linkage disequilibrium block of polymorphisms located in the HLA class II region surpassed the genome-wide level of significance (OR?=?0.56, 95% CI?=?0.46-0.68). Although no polymorphic amino acid positions were associated at the genome-wide level of significance, P-values of potential relevance were observed for the positions 13 and 11 of HLA-DRB1 (P?=?6.67E-05, P?=?1.88E-05, respectively). Outside the HLA, potential associations were detected, but none of them were close to the statistical significance. In conclusion, our study suggests that IgA vasculitis is an archetypal HLA class II disease. |*Genetic Loci [MESH] |*Genetic Predisposition to Disease [MESH] |*Genome-Wide Association Study [MESH] |Histocompatibility Antigens Class II/*genetics [MESH] |Humans [MESH] |Immunoglobulin A/*immunology [MESH] |Logistic Models [MESH]A genome-wide association study suggests the HLA Class II region as th(epmc).pdf DeepDyve Pubget Overpricing