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10.2169/internalmedicine.56.8199

http://scihub22266oqcxt.onion/10.2169/internalmedicine.56.8199
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C5505917!5505917!28626187
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suck abstract from ncbi


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pmid28626187      Intern+Med 2017 ; 56 (12): 1575-80
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  • Efficacy of Intravenous Cyclophosphamide Pulse Therapy for P-Glycoprotein-expressing B Cell-associated Active True Renal Lupus Vasculitis in Lupus Nephritis #MMPMID28626187
  • Kawabe A; Tsujimura S; Saito K; Tanaka Y
  • Intern Med 2017[Jun]; 56 (12): 1575-80 PMID28626187show ga
  • True renal lupus vasculitis (TRLV), a vascular lesion usually associated with proliferative lupus nephritis (LN), is resistant to conventional treatments. The expression of P-glycoprotein (P-gp) on activated lymphocytes causes drug resistance. We herein report a patient with TRLV, minimal change LN, overexpression of P-gp on peripheral B cells, and accumulation of P-gp+ B cells at the site of TRLV. High-dose corticosteroids combined with intravenous cyclophosphamide pulse therapy resulted in clinical remission and the long-term normal renal function.
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