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10.2169/internalmedicine.56.8199

http://scihub22266oqcxt.onion/10.2169/internalmedicine.56.8199
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C5505917!5505917 !28626187
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suck abstract from ncbi


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pmid28626187
      Intern+Med 2017 ; 56 (12 ): 1575-1580
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  • Efficacy of Intravenous Cyclophosphamide Pulse Therapy for P-Glycoprotein-expressing B Cell-associated Active True Renal Lupus Vasculitis in Lupus Nephritis #MMPMID28626187
  • Kawabe A ; Tsujimura S ; Saito K ; Tanaka Y
  • Intern Med 2017[]; 56 (12 ): 1575-1580 PMID28626187 show ga
  • True renal lupus vasculitis (TRLV), a vascular lesion usually associated with proliferative lupus nephritis (LN), is resistant to conventional treatments. The expression of P-glycoprotein (P-gp) on activated lymphocytes causes drug resistance. We herein report a patient with TRLV, minimal change LN, overexpression of P-gp on peripheral B cells, and accumulation of P-gp(+) B cells at the site of TRLV. High-dose corticosteroids combined with intravenous cyclophosphamide pulse therapy resulted in clinical remission and the long-term normal renal function.
  • |ATP Binding Cassette Transporter, Subfamily B, Member 1/biosynthesis [MESH]
  • |B-Lymphocytes/metabolism [MESH]
  • |Cyclophosphamide/administration & dosage/*therapeutic use [MESH]
  • |Drug Administration Schedule [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Immunosuppressive Agents/administration & dosage/*therapeutic use [MESH]
  • |Kidney/pathology [MESH]
  • |Lupus Nephritis/*drug therapy [MESH]
  • |Vasculitis/drug therapy [MESH]


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