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2017 ; 56
(12
): 1543-1547
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English Wikipedia
Long-term Low-density Lipoprotein Apheresis in a Patient with Refractory
Idiopathic Membranous Glomerulonephritis
#MMPMID28626181
Yabuuchi J
; Suwabe T
; Mizuno H
; Ueno T
; Hoshino J
; Sekine A
; Kawada M
; Yamanouchi M
; Hayami N
; Hiramatsu R
; Hasegawa E
; Sawa N
; Takaichi K
; Fujii T
; Ohashi K
; Ubara Y
Intern Med
2017[]; 56
(12
): 1543-1547
PMID28626181
show ga
A 61-year-old Japanese man developed nephrotic syndrome (NS) due to idiopathic
membranous glomerulonephritis (MGN). He received immunosuppressive therapy for
two years, including prednisolone, cyclophosphamide, and cyclosporine A, but the
NS persisted. Low-density lipoprotein apheresis (LDL-A) was initiated at a
frequency of twice a month and continued for 9 years (203 sessions in total). His
proteinuria reduced to less than 1 g daily after 9 years. LDL-A was stopped, and
the NS has not relapsed for five years. This case suggests that long-term LDL-A
therapy may be a treatment option for idiopathic MGN refractory to
immunosuppressive therapy or short-term LDL-A.