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10.7554/eLife.27134 http://scihub22266oqcxt.onion/10.7554/eLife.27134 C5505699!5505699!28693721     free     free     free       eLife 2017 ; 6 (ä): ä Nephropedia Template TP {{tp|p=28693721|t=2017. Mitosis can drive cell cannibalism through entosis |pdf=|usr=}}{{28693721}} gab.com Text Mitosis can drive cell cannibalism through entosis JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=28693721 #FOAvip Entosis is a form of epithelial cell cannibalism that is prevalent in human cancer, typically triggered by loss of matrix adhesion. Here, we report an alternative mechanism for entosis in human epithelial cells, driven by mitosis. Mitotic entosis is regulated by Cdc42, which controls mitotic morphology. Cdc42 depletion enhances mitotic deadhesion and rounding, and these biophysical changes, which depend on RhoA activation and are phenocopied by Rap1 inhibition, permit subsequent entosis. Mitotic entosis occurs constitutively in some human cancer cell lines and mitotic index correlates with cell cannibalism in primary human breast tumours. Adherent, wild-type cells can act efficiently as entotic hosts, suggesting that normal epithelia may engulf and kill aberrantly dividing neighbours. Finally, we report that Paclitaxel/taxol promotes mitotic rounding and subsequent entosis, revealing an unconventional activity of this drug. Together, our data uncover an intriguing link between cell division and cannibalism, of significance to both cancer and chemotherapy.DOI:http://dx.doi.org/10.7554/eLife.27134.001 Twit Text FOAVip Mitosis can drive cell cannibalism through entosis ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=28693721 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28693721 #FOAvip English Wikipedia <ref>{{Cite pmid|28693721}}</ref> Mitosis can drive cell cannibalism through entosis #MMPMID28693721 Durgan J; Tseng YY; Hamann JC; Domart MC; Collinson L; Hall A; Overholtzer M; Florey O eLife 2017[]; 6 (ä): ä PMID28693721show ga Entosis is a form of epithelial cell cannibalism that is prevalent in human cancer, typically triggered by loss of matrix adhesion. Here, we report an alternative mechanism for entosis in human epithelial cells, driven by mitosis. Mitotic entosis is regulated by Cdc42, which controls mitotic morphology. Cdc42 depletion enhances mitotic deadhesion and rounding, and these biophysical changes, which depend on RhoA activation and are phenocopied by Rap1 inhibition, permit subsequent entosis. Mitotic entosis occurs constitutively in some human cancer cell lines and mitotic index correlates with cell cannibalism in primary human breast tumours. Adherent, wild-type cells can act efficiently as entotic hosts, suggesting that normal epithelia may engulf and kill aberrantly dividing neighbours. Finally, we report that Paclitaxel/taxol promotes mitotic rounding and subsequent entosis, revealing an unconventional activity of this drug. Together, our data uncover an intriguing link between cell division and cannibalism, of significance to both cancer and chemotherapy.DOI:http://dx.doi.org/10.7554/eLife.27134.001 äMitosis can drive cell cannibalism through entosis (epmc).pdf DeepDyve Pubget Overpricing