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10.1016/j.immuni.2017.04.016 http://scihub22266oqcxt.onion/10.1016/j.immuni.2017.04.016 C5505665!5505665!28514673     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2017 ; 46 (5): 714-29 Nephropedia Template TP {{tp|p=28514673|t=2017. Metabolic and epigenetic coordination of T cell and Macrophage immunity |pdf=|usr=}}{{28514673}} gab.com Text Metabolic and epigenetic coordination of T cell and Macrophage immunity JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=28514673 #FOAvip Recognition of pathogens by innate and adaptive immune cells instructs rapid alterations of cellular processes to promote effective resolution of infection. To accommodate increased bioenergetic and biosynthetic demands, metabolic pathways are harnessed to maximize proliferation and effector molecule production. In parallel, activation initiates context-specific gene-expression programs that drive effector functions and cell fates that correlate with changes in epigenetic landscapes. Many chromatin- and DNA-modifying enzymes make use of substrates and cofactors that are intermediates of metabolic pathways, providing potential cross talk between metabolism and epigenetic regulation of gene expression. In this review, we discuss recent studies of T cells and macrophages supporting a role for metabolic activity in integrating environmental signals with activation-induced gene-expression programs through modulation of the epigenome and speculate as to how this may influence context-specific macrophage and T cell responses to infection. Twit Text FOAVip Metabolic and epigenetic coordination of T cell and Macrophage immunity ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=28514673 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28514673 #FOAvip English Wikipedia <ref>{{Cite pmid|28514673}}</ref> Metabolic and epigenetic coordination of T cell and Macrophage immunity #MMPMID28514673 Phan AT; Goldrath AW; Glass CK Immunity 2017[May]; 46 (5): 714-29 PMID28514673show ga Recognition of pathogens by innate and adaptive immune cells instructs rapid alterations of cellular processes to promote effective resolution of infection. To accommodate increased bioenergetic and biosynthetic demands, metabolic pathways are harnessed to maximize proliferation and effector molecule production. In parallel, activation initiates context-specific gene-expression programs that drive effector functions and cell fates that correlate with changes in epigenetic landscapes. Many chromatin- and DNA-modifying enzymes make use of substrates and cofactors that are intermediates of metabolic pathways, providing potential cross talk between metabolism and epigenetic regulation of gene expression. In this review, we discuss recent studies of T cells and macrophages supporting a role for metabolic activity in integrating environmental signals with activation-induced gene-expression programs through modulation of the epigenome and speculate as to how this may influence context-specific macrophage and T cell responses to infection. äMetabolic and epigenetic coordination of T cell and Macrophage immunit(epmc).pdf DeepDyve Pubget Overpricing