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10.4049/jimmunol.1601570 http://scihub22266oqcxt.onion/10.4049/jimmunol.1601570 C5505653!5505653!28550202     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2017 ; 199 (1): 91-6 Nephropedia Template TP {{tp|p=28550202|t=2017. Antigen specific T cell analysis reveals active immune responses to beta cell antigens are focused on a unique set of epitopes1 |pdf=|usr=}}{{28550202}} gab.com Text Antigen specific T cell analysis reveals active immune responses to beta cell antigens are focused on a unique set of epitopes1 JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28550202 #FOAvip CD38 is an activation marker that is present on recently activated T cells, but absent on resting memory T cells. In this study, we show that CD45RO+CD38+ beta cell antigen-specific CD4+ T cells were present at higher frequencies in T1D subjects compared to those in healthy subjects. These results imply an ongoing beta cell immunity years after onset of diabetes and suggest these activated T cells have an active role in the disease process. The antigen specificities of these activated T cells were determined by a novel CD154 T cell epitope mapping assay. While each patient usually had a unique set of epitopes recognized by these T cells, two epitopes, DR0401 restricted modified preproinsulin peptide (PPI78-90K88S) and ZnT266-285, were repeatedly identified in multiple subjects. Identifying these T cells and their specific antigenic epitopes might provide immunotherapeutic targets for personalized therapies. Twit Text FOAVip Antigen specific T cell analysis reveals active immune responses to beta cell antigens are focused on a unique set of epitopes1 ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28550202 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28550202 #FOAvip English Wikipedia <ref>{{Cite pmid|28550202}}</ref> Antigen specific T cell analysis reveals active immune responses to beta cell antigens are focused on a unique set of epitopes1 #MMPMID28550202 Yang J; Wen X; Xu H; Torres-Chinn N; Speake C; Greenbaum CJ; Nepom GT; Kwok WW J Immunol 2017[Jul]; 199 (1): 91-6 PMID28550202show ga CD38 is an activation marker that is present on recently activated T cells, but absent on resting memory T cells. In this study, we show that CD45RO+CD38+ beta cell antigen-specific CD4+ T cells were present at higher frequencies in T1D subjects compared to those in healthy subjects. These results imply an ongoing beta cell immunity years after onset of diabetes and suggest these activated T cells have an active role in the disease process. The antigen specificities of these activated T cells were determined by a novel CD154 T cell epitope mapping assay. While each patient usually had a unique set of epitopes recognized by these T cells, two epitopes, DR0401 restricted modified preproinsulin peptide (PPI78-90K88S) and ZnT266-285, were repeatedly identified in multiple subjects. Identifying these T cells and their specific antigenic epitopes might provide immunotherapeutic targets for personalized therapies. äAntigen specific T cell analysis reveals active immune responses to be(epmc).pdf DeepDyve Pubget Overpricing