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10.1016/j.virol.2017.03.002 http://scihub22266oqcxt.onion/10.1016/j.virol.2017.03.002 C5505171!5505171 !28340355     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28340355 &cmd=llinks): Failed to open stream: HTTP request failed! 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The Human Immunodeficiency Virus 1 ASP RNA promotes viral latency by recruiting the Polycomb Repressor Complex 2 and promoting nucleosome assembly |pdf=|usr=}}{{28340355 }} gab.com Text The Human Immunodeficiency Virus 1 ASP RNA promotes viral latency by recruiting the Polycomb Repressor Complex 2 and promoting nucleosome assembly JO: Virology http://www.kidney.de/pget.php?&tw=1&pmid=28340355 #FOAvip Various epigenetic marks at the HIV-1 5'LTR suppress proviral expression and promote latency. Cellular antisense transcripts known as long noncoding RNAs (lncRNAs) recruit the polycomb repressor complex 2 (PRC2) to gene promoters, which catalyzes trimethylation of lysine 27 on histone H3 (H3K27me3), thus promoting nucleosome assembly and suppressing gene expression. We found that an HIV-1 antisense transcript expressed from the 3'LTR and encoding the antisense protein ASP promotes proviral latency. Expression of ASP RNA reduced HIV-1 replication in Jurkat cells. Moreover, ASP RNA expression promoted the establishment and maintenance of HIV-1 latency in Jurkat E4 cells. We show that this transcript interacts with and recruits PRC2 to the HIV-1 5'LTR, increasing accumulation of the suppressive epigenetic mark H3K27me3, while reducing RNA Polymerase II and thus proviral transcription. Altogether, our results suggest that the HIV-1 ASP transcript promotes epigenetic silencing of the HIV-1 5'LTR and proviral latency through the PRC2 pathway. Twit Text FOAVip The Human Immunodeficiency Virus 1 ASP RNA promotes viral latency by recruiting the Polycomb Repressor Complex 2 and promoting nucleosome assembly ????Virology http://www.kidney.de/pget.php?&tw=1&pmid=28340355 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28340355 #FOAvip English Wikipedia <ref>{{Cite pmid|28340355 }}</ref> The Human Immunodeficiency Virus 1 ASP RNA promotes viral latency by recruiting the Polycomb Repressor Complex 2 and promoting nucleosome assembly #MMPMID28340355 Zapata JC ; Campilongo F ; Barclay RA ; DeMarino C ; Iglesias-Ussel MD ; Kashanchi F ; Romerio F Virology 2017[Jun]; 506 (ä): 34-44 PMID28340355 show ga Various epigenetic marks at the HIV-1 5'LTR suppress proviral expression and promote latency. Cellular antisense transcripts known as long noncoding RNAs (lncRNAs) recruit the polycomb repressor complex 2 (PRC2) to gene promoters, which catalyzes trimethylation of lysine 27 on histone H3 (H3K27me3), thus promoting nucleosome assembly and suppressing gene expression. We found that an HIV-1 antisense transcript expressed from the 3'LTR and encoding the antisense protein ASP promotes proviral latency. Expression of ASP RNA reduced HIV-1 replication in Jurkat cells. Moreover, ASP RNA expression promoted the establishment and maintenance of HIV-1 latency in Jurkat E4 cells. We show that this transcript interacts with and recruits PRC2 to the HIV-1 5'LTR, increasing accumulation of the suppressive epigenetic mark H3K27me3, while reducing RNA Polymerase II and thus proviral transcription. Altogether, our results suggest that the HIV-1 ASP transcript promotes epigenetic silencing of the HIV-1 5'LTR and proviral latency through the PRC2 pathway. |*Virus Latency [MESH] |Chromatin Assembly and Disassembly [MESH] |Gene Expression Regulation, Viral [MESH] |Gene Silencing [MESH] |HIV Infections/genetics/metabolism/*virology [MESH] |HIV Long Terminal Repeat [MESH] |HIV-1/genetics/*physiology [MESH] |Histones/metabolism [MESH] |Host-Pathogen Interactions [MESH] |Humans [MESH] |Nucleosomes/genetics/*metabolism [MESH] |Polycomb Repressive Complex 2/genetics/*metabolism [MESH] |RNA, Antisense/genetics/*metabolism [MESH]The Human Immunodeficiency Virus 1 ASP RNA promotes viral latency by r(epmc).pdf DeepDyve Pubget Overpricing