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10.7150/thno.19091 http://scihub22266oqcxt.onion/10.7150/thno.19091 C5505058!5505058 !28740549     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28740549 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Theranostics 2017 ; 7 (8 ): 2261-2276 Nephropedia Template TP {{tp|p=28740549 |t=2017. Targeted Delivery to Tumor-associated Pericytes via an Affibody with High Affinity for PDGFR? Enhances the in vivo Antitumor Effects of Human TRAIL |pdf=|usr=}}{{28740549 }} gab.com Text Targeted Delivery to Tumor-associated Pericytes via an Affibody with High Affinity for PDGFR Enhances the in vivo Antitumor Effects of Human TRAIL JO: Theranostics http://www.kidney.de/pget.php?&tw=1&pmid=28740549 #FOAvip Human tumor necrosis factor-related apoptosis-inducing ligand (hTRAIL) has exhibited superior in vitro cytotoxicity in a variety of tumor cells. However, hTRAIL showed a disappointing anticancer effect in clinical trials, although hTRAIL-based regimens were well tolerated. One important reason might be that hTRAIL was largely trapped by its decoy receptors, which are ubiquitously expressed on normal cells. Tumor-targeted delivery might improve the tumor uptake and thus enhance the antitumor effect of hTRAIL. Platelet-derived growth factor receptor ? (PDGFR?)-expressing pericytes are enriched in tumor tissues derived both from patients with colon cancer and from mice bearing colorectal tumor xenografts. A Z(PDGFR?) affibody showed high affinity (nM) for PDGFR? and was predominantly distributed on tumor-associated PDGFR?-positive pericytes. Co-administration with the Z(PDGFR?) affibody did not significantly enhance the antitumor effect of hTRAIL in mice bearing tumor xenografts. Fusion to the Z(PDGFR?) affibody endows hTRAIL with PDGFR?-binding ability but does not interfere with its death receptor binding and activation. The fused Z(PDGFR?) affibody mediated PDGFR?-dependent binding of hTRAIL to pericytes. In addition, hTRAIL bound on pericytes could kill tumor cells through juxtatropic activity or exhibit cytotoxicity in tumor cells after being released from pericytes. Intravenously injected hTRAIL fused to Z(PDGFR?) affibody initially accumulated on tumor-associated pericytes and then diffused to the tumor parenchyma over time. Fusion to the Z(PDGFR?) affibody increased the tumor uptake of hTRAIL, thus enhancing the antitumor effect of hTRAIL in mice bearing tumor xenografts. These results demonstrate that pericyte-targeted delivery mediated by a Z(PDGFR?) affibody is an alternative strategy for tumor-targeted delivery of anticancer agents. Twit Text FOAVip Targeted Delivery to Tumor-associated Pericytes via an Affibody with High Affinity for PDGFR Enhances the in vivo Antitumor Effects of Human TRAIL ????Theranostics http://www.kidney.de/pget.php?&tw=1&pmid=28740549 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28740549 #FOAvip English Wikipedia <ref>{{Cite pmid|28740549 }}</ref> Targeted Delivery to Tumor-associated Pericytes via an Affibody with High Affinity for PDGFR? Enhances the in vivo Antitumor Effects of Human TRAIL #MMPMID28740549 Tao Z ; Yang H ; Shi Q ; Fan Q ; Wan L ; Lu X Theranostics 2017[]; 7 (8 ): 2261-2276 PMID28740549 show ga Human tumor necrosis factor-related apoptosis-inducing ligand (hTRAIL) has exhibited superior in vitro cytotoxicity in a variety of tumor cells. However, hTRAIL showed a disappointing anticancer effect in clinical trials, although hTRAIL-based regimens were well tolerated. One important reason might be that hTRAIL was largely trapped by its decoy receptors, which are ubiquitously expressed on normal cells. Tumor-targeted delivery might improve the tumor uptake and thus enhance the antitumor effect of hTRAIL. Platelet-derived growth factor receptor ? (PDGFR?)-expressing pericytes are enriched in tumor tissues derived both from patients with colon cancer and from mice bearing colorectal tumor xenografts. A Z(PDGFR?) affibody showed high affinity (nM) for PDGFR? and was predominantly distributed on tumor-associated PDGFR?-positive pericytes. Co-administration with the Z(PDGFR?) affibody did not significantly enhance the antitumor effect of hTRAIL in mice bearing tumor xenografts. Fusion to the Z(PDGFR?) affibody endows hTRAIL with PDGFR?-binding ability but does not interfere with its death receptor binding and activation. The fused Z(PDGFR?) affibody mediated PDGFR?-dependent binding of hTRAIL to pericytes. In addition, hTRAIL bound on pericytes could kill tumor cells through juxtatropic activity or exhibit cytotoxicity in tumor cells after being released from pericytes. Intravenously injected hTRAIL fused to Z(PDGFR?) affibody initially accumulated on tumor-associated pericytes and then diffused to the tumor parenchyma over time. Fusion to the Z(PDGFR?) affibody increased the tumor uptake of hTRAIL, thus enhancing the antitumor effect of hTRAIL in mice bearing tumor xenografts. These results demonstrate that pericyte-targeted delivery mediated by a Z(PDGFR?) affibody is an alternative strategy for tumor-targeted delivery of anticancer agents. |Administration, Intravenous [MESH] |Animals [MESH] |Autoantibodies/genetics/*metabolism [MESH] |Biological Products/administration & dosage/*pharmacokinetics/*pharmacology [MESH] |Cells, Cultured [MESH] |Colorectal Neoplasms/*therapy [MESH] |Disease Models, Animal [MESH] |Heterografts [MESH] |Humans [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |Neoplasm Transplantation [MESH] |Pericytes/*drug effects/physiology [MESH] |Receptor, Platelet-Derived Growth Factor beta/*metabolism [MESH] |Recombinant Fusion Proteins/genetics/metabolism [MESH] |TNF-Related Apoptosis-Inducing Ligand/genetics/*metabolism [MESH]Targeted Delivery to Tumor-associated Pericytes via an Affibody with H(epmc).pdf DeepDyve Pubget Overpricing