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10.3892/ijmm.2017.3027 http://scihub22266oqcxt.onion/10.3892/ijmm.2017.3027 C5505025!5505025!28627599     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Med 2017 ; 40 (2): 411-7 Nephropedia Template TP {{tp|p=28627599|t=2017. HMOX-1 inhibits TGF-?-induced epithelial-mesenchymal transition in the MCF-7 breast cancer cell line |pdf=|usr=}}{{28627599}} gab.com Text HMOX-1 inhibits TGF- -induced epithelial-mesenchymal transition in the MCF-7 breast cancer cell line JO: Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28627599 #FOAvip Epithelial-mesenchymal transition (EMT) is a key mechanism underlying metastatic breast cancer. Reactive oxygen species (ROS) play an important role in EMT. Heme oxygenase-1 (HMOX-1) can reduce oxidative stress. However, the effect of HMOX-1 on the EMT process in breast cancer cells is unknown. We treated the MCF-7 breast cancer cell line with the HMOX-1 inducer hemin and observed that hemin induced HMOX-1 expression and inhibited migration, invasion and ROS generation in transforming growth factor-? (TGF-?)-treated MCF-7 cells using quantitative RT-qPCR, western blotting, wound-healing and cell invasion assays as well as fluorescent probe DCFDA. Hemin inhibited TGF-?-induced EMT in the MCF-7 cells, whereas HMOX-1 siRNA attenuated the suppressive effect of hemin as determined by the expression and cellular distribution of selected EMT markers. In summary, our results revealed that hemin treatment increased HMOX-1 expression and inhibited TGF-?-induced EMT in MCF-7 cells. Twit Text FOAVip HMOX-1 inhibits TGF- -induced epithelial-mesenchymal transition in the MCF-7 breast cancer cell line ????Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28627599 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28627599 #FOAvip English Wikipedia <ref>{{Cite pmid|28627599}}</ref> HMOX-1 inhibits TGF-?-induced epithelial-mesenchymal transition in the MCF-7 breast cancer cell line #MMPMID28627599 Zhu X; Huang S; Zeng L; Ma J; Sun S; Zeng F; Kong F; Cheng X Int J Mol Med 2017[Aug]; 40 (2): 411-7 PMID28627599show ga Epithelial-mesenchymal transition (EMT) is a key mechanism underlying metastatic breast cancer. Reactive oxygen species (ROS) play an important role in EMT. Heme oxygenase-1 (HMOX-1) can reduce oxidative stress. However, the effect of HMOX-1 on the EMT process in breast cancer cells is unknown. We treated the MCF-7 breast cancer cell line with the HMOX-1 inducer hemin and observed that hemin induced HMOX-1 expression and inhibited migration, invasion and ROS generation in transforming growth factor-? (TGF-?)-treated MCF-7 cells using quantitative RT-qPCR, western blotting, wound-healing and cell invasion assays as well as fluorescent probe DCFDA. Hemin inhibited TGF-?-induced EMT in the MCF-7 cells, whereas HMOX-1 siRNA attenuated the suppressive effect of hemin as determined by the expression and cellular distribution of selected EMT markers. In summary, our results revealed that hemin treatment increased HMOX-1 expression and inhibited TGF-?-induced EMT in MCF-7 cells. äHMOX-1 inhibits TGF-?-induced epithelial-mesenchymal transition in the(epmc).pdf DeepDyve Pubget Overpricing