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10.3892/ijmm.2017.3020 http://scihub22266oqcxt.onion/10.3892/ijmm.2017.3020 C5504974!5504974!28627585     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Med 2017 ; 40 (2): 303-10 Nephropedia Template TP {{tp|p=28627585|t=2017. Role of metadherin in estrogen-regulated gene expression |pdf=|usr=}}{{28627585}} gab.com Text Role of metadherin in estrogen-regulated gene expression JO: Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28627585 #FOAvip The disruption of estrogen signaling is widely associated with the development of breast, endometrial and ovarian cancers. As a multifunctional mediator of carcinogenesis, metadherin (MTDH)/astrocyte elevated gene-1 (AEG-1) overexpression has been associated with numerous types of cancer, with reported roles in tumor initiation, proliferation, invasion, metastasis and chemoresistance. At the molecular level, MTDH has been shown to interact with proteins that drive tumorigenesis, including nuclear factor-?B (NF-?B), promyelocytic leukaemia zinc finger (PLZF), BRCA2- and CDKN1A (p21Cip1/Waf-1/mda-6)-interacting protein ? (BCCIP?) and staphylococcal nuclease and tudor domain containing 1 (SND1). Through the analysis of the Cancer Genome Atlas (TCGA) datasets for estrogen receptor (ER)-positive endometrial and breast cancers, we found that over 25% of all gene expression correlated with MTDH. Using Affymetrix microarrays, we characterized the differences in gene expression between estrogen-treated parental and MTDH-deficient endometrial and breast cancer cells. We also explored a possible interaction between MTDH and ER by immunoprecipitation, and found that MTDH and ER associated in both breast and endometrial cancer cells in response to estrogen. Reciprocal co-immunoprecipitation analysis demonstrated that acute estrogen stimulation promoted the interaction of MTDH with ER in the nucleus. These data, to the best of our knowledge, provide the first evidence that MTDH and ER? interact in the nucleus with estrogen treatment to regulate gene expression. Twit Text FOAVip Role of metadherin in estrogen-regulated gene expression ????Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28627585 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28627585 #FOAvip English Wikipedia <ref>{{Cite pmid|28627585}}</ref> Role of metadherin in estrogen-regulated gene expression #MMPMID28627585 Li Y; Bosquet JG; Yang S; Thiel KW; Zhang Y; Liu H; Leslie KK; Meng X Int J Mol Med 2017[Aug]; 40 (2): 303-10 PMID28627585show ga The disruption of estrogen signaling is widely associated with the development of breast, endometrial and ovarian cancers. As a multifunctional mediator of carcinogenesis, metadherin (MTDH)/astrocyte elevated gene-1 (AEG-1) overexpression has been associated with numerous types of cancer, with reported roles in tumor initiation, proliferation, invasion, metastasis and chemoresistance. At the molecular level, MTDH has been shown to interact with proteins that drive tumorigenesis, including nuclear factor-?B (NF-?B), promyelocytic leukaemia zinc finger (PLZF), BRCA2- and CDKN1A (p21Cip1/Waf-1/mda-6)-interacting protein ? (BCCIP?) and staphylococcal nuclease and tudor domain containing 1 (SND1). Through the analysis of the Cancer Genome Atlas (TCGA) datasets for estrogen receptor (ER)-positive endometrial and breast cancers, we found that over 25% of all gene expression correlated with MTDH. Using Affymetrix microarrays, we characterized the differences in gene expression between estrogen-treated parental and MTDH-deficient endometrial and breast cancer cells. We also explored a possible interaction between MTDH and ER by immunoprecipitation, and found that MTDH and ER associated in both breast and endometrial cancer cells in response to estrogen. Reciprocal co-immunoprecipitation analysis demonstrated that acute estrogen stimulation promoted the interaction of MTDH with ER in the nucleus. These data, to the best of our knowledge, provide the first evidence that MTDH and ER? interact in the nucleus with estrogen treatment to regulate gene expression. äRole of metadherin in estrogen-regulated gene expression (epmc).pdf DeepDyve Pubget Overpricing