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10.1186/s12929-017-0349-5 http://scihub22266oqcxt.onion/10.1186/s12929-017-0349-5 C5504791!5504791!28697735     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28697735&cmd=llinks): Failed to open stream: HTTP request failed! 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V-J combinations of T-cell receptor predict responses to erythropoietin in end-stage renal disease patients |pdf=|usr=}}{{28697735}} gab.com Text V-J combinations of T-cell receptor predict responses to erythropoietin in end-stage renal disease patients JO: J Biomed Sci http://www.kidney.de/pget.php?&tw=1&pmid=28697735 #FOAvip Background: Anemia is common among end-stage renal disease (ESRD) patients who undergone hemodialysis. The total reduction of red blood cell (RBC) count is associated with poor prognosis in these patients. Although erythropoietin (EPO) has been used as an effective treatment for ESRD patients with anemia, a large number of patients still present poor responses to EPO treatment. Methods: We measured T-cell receptor sequencing profiles, including length of complementarity-deteremining region 3 (CDR3), intra- and inter-group (EPO resistant vs. responsive) clonotype diversity, V(D)J usage profiles and V-J combinations from ESRD patients and to investigate the correlation between these features and EPO treatment efficacy. Results: Our results revealed statistical significance in the top 3 ~ 15 most abundant joint distributions of V?/J? among the two groups, suggesting the importance of V or J gene utilization in the EPO response of ESRD patients. Conclusions: In summary, we provided evidence addressing the potential correlation between the immune repertoire and EPO response in ESRD patients. Trial registration: TMU-JIRB 201309026. Registered 16 October 2013. Electronic supplementary material: The online version of this article (doi:10.1186/s12929-017-0349-5) contains supplementary material, which is available to authorized users. Twit Text FOAVip V-J combinations of T-cell receptor predict responses to erythropoietin in end-stage renal disease patients ????J Biomed Sci http://www.kidney.de/pget.php?&tw=1&pmid=28697735 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28697735 #FOAvip English Wikipedia <ref>{{Cite pmid|28697735}}</ref> V-J combinations of T-cell receptor predict responses to erythropoietin in end-stage renal disease patients #MMPMID28697735 Wong HSC; Chang CM; Kao CC; Hsu YW; Liu X; Chang WC; Wu MS; Chang WC J Biomed Sci 2017[]; 24 (ä): ä PMID28697735show ga Background: Anemia is common among end-stage renal disease (ESRD) patients who undergone hemodialysis. The total reduction of red blood cell (RBC) count is associated with poor prognosis in these patients. Although erythropoietin (EPO) has been used as an effective treatment for ESRD patients with anemia, a large number of patients still present poor responses to EPO treatment. Methods: We measured T-cell receptor sequencing profiles, including length of complementarity-deteremining region 3 (CDR3), intra- and inter-group (EPO resistant vs. responsive) clonotype diversity, V(D)J usage profiles and V-J combinations from ESRD patients and to investigate the correlation between these features and EPO treatment efficacy. Results: Our results revealed statistical significance in the top 3 ~ 15 most abundant joint distributions of V?/J? among the two groups, suggesting the importance of V or J gene utilization in the EPO response of ESRD patients. Conclusions: In summary, we provided evidence addressing the potential correlation between the immune repertoire and EPO response in ESRD patients. Trial registration: TMU-JIRB 201309026. Registered 16 October 2013. Electronic supplementary material: The online version of this article (doi:10.1186/s12929-017-0349-5) contains supplementary material, which is available to authorized users. äV-J combinations of T-cell receptor predict responses to erythropoieti(epmc).pdf DeepDyve Pubget Overpricing