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10.1186/s12866-017-1062-y http://scihub22266oqcxt.onion/10.1186/s12866-017-1062-y C5504769!5504769 !28693414     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28693414 &cmd=llinks): Failed to open stream: HTTP request failed! 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Hypothetical protein Cpn0423 triggers NOD2 activation and contributes to Chlamydia pneumoniae-mediated inflammation |pdf=|usr=}}{{28693414 }} gab.com Text Hypothetical protein Cpn0423 triggers NOD2 activation and contributes to Chlamydia pneumoniae-mediated inflammation JO: BMC Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=28693414 #FOAvip BACKGROUND: Chlamydia pneumoniae (C. pneumoniae) is pathogenic to humans, by causing pulmonary inflammation or bronchitis in both adolescents and young adults. However, the molecular signals linking C. pneumoniae components to inflammation remain elusive. This study was to investigate the effect of Chlamydia-specific Cpn0423 of C. pneumoniae on C. pneumoniae-mediated inflammation. RESULTS: Cpn0423 was detected outside of C. pneumoniae inclusions, which induced production of several cytokines including macrophage inflammatory protein-2 (MIP-2) and interleukins (ILs). Production of the Cpn0423-induced cytokines was markedly reduced in cells pretreated with NOD2-siRNA, but not with negative control oligonucleotides. Mice treated with Cpn0423 through intranasal administration exhibited pulmonary inflammation as evidenced by infiltration of inflammatory cells, increased inflammatory scores in the lung histology, recruitment of neutrophils and increased cytokines levels in the BALF. CONCLUSION: Cpn0423 could be sensed by NOD2, which was identified as an essential element in a pathway contributing to the development of C. pneumoniae -mediated inflammation. Twit Text FOAVip Hypothetical protein Cpn0423 triggers NOD2 activation and contributes to Chlamydia pneumoniae-mediated inflammation ????BMC Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=28693414 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28693414 #FOAvip English Wikipedia <ref>{{Cite pmid|28693414 }}</ref> Hypothetical protein Cpn0423 triggers NOD2 activation and contributes to Chlamydia pneumoniae-mediated inflammation #MMPMID28693414 Chen HL ; Dai GZ ; Zhou AW ; Li RH ; Yuan HX ; Xiang J ; You XX ; Ran O ; Wu YM BMC Microbiol 2017[Jul]; 17 (1 ): 153 PMID28693414 show ga BACKGROUND: Chlamydia pneumoniae (C. pneumoniae) is pathogenic to humans, by causing pulmonary inflammation or bronchitis in both adolescents and young adults. However, the molecular signals linking C. pneumoniae components to inflammation remain elusive. This study was to investigate the effect of Chlamydia-specific Cpn0423 of C. pneumoniae on C. pneumoniae-mediated inflammation. RESULTS: Cpn0423 was detected outside of C. pneumoniae inclusions, which induced production of several cytokines including macrophage inflammatory protein-2 (MIP-2) and interleukins (ILs). Production of the Cpn0423-induced cytokines was markedly reduced in cells pretreated with NOD2-siRNA, but not with negative control oligonucleotides. Mice treated with Cpn0423 through intranasal administration exhibited pulmonary inflammation as evidenced by infiltration of inflammatory cells, increased inflammatory scores in the lung histology, recruitment of neutrophils and increased cytokines levels in the BALF. CONCLUSION: Cpn0423 could be sensed by NOD2, which was identified as an essential element in a pathway contributing to the development of C. pneumoniae -mediated inflammation. |Animals [MESH] |Bacterial Proteins/genetics/*immunology [MESH] |Chemokine CXCL2/genetics/immunology [MESH] |Chlamydophila Infections/genetics/*immunology/microbiology [MESH] |Chlamydophila pneumoniae/genetics/*immunology [MESH] |Humans [MESH] |Inflammation Mediators/*immunology [MESH] |Interleukins/genetics/immunology [MESH] |Lung/immunology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Nod2 Signaling Adaptor Protein/genetics/*immunology [MESH]Hypothetical protein Cpn0423 triggers NOD2 activation and contributes (epmc).pdf DeepDyve Pubget Overpricing