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10.1186/s12882-017-0636-0 http://scihub22266oqcxt.onion/10.1186/s12882-017-0636-0 C5504660!5504660 !28693446     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28693446 &cmd=llinks): Failed to open stream: HTTP request failed! 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Response to immunosuppressive therapy in PLA(2)R- associated and non-PLA(2)R- associated idiopathic membranous nephropathy: a retrospective, multicenter cohort study |pdf=|usr=}}{{28693446 }} gab.com Text Response to immunosuppressive therapy in PLA(2)R- associated and non-PLA(2)R- associated idiopathic membranous nephropathy: a retrospective, multicenter cohort study JO: BMC Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=28693446 #FOAvip BACKGROUND: According to renal M type phospholipase A(2) receptor (PLA(2)R) immunohistochemistry, idiopathic membranous nephropathy (IMN) could be categorized into PLA(2)R-associated and non-PLA(2)R-associated IMN. We conducted a retrospective, multicenter cohort study with 91 patients to compare the effect of immunosuppressive therapy between PLA(2)R-associated and non-PLA(2)R-associated IMN patients. METHODS: A total of 91 biopsy-proven IMN patients from Huashan hospital and People's Hospital of Wuxi in past 5 years were collected into this study. IMN with positive PLA(2)R immunohistochemistry in kidney biopsies were designated as PLA(2)R-associated IMN. Seventy-eight of the 91 IMN patients was PLA(2)R-associated IMN and 13 were non-PLA(2)R-associated IMN. Forty-five patients were treated with prednisone plus cyclophosphamide (CTX), and 46 with prednisone plus calcineurin inhibitors (CNIs). The follow-up duration was 15 months. RESULTS: The total remission rate (76.9% versus 44.9%, p = 0.032) and complete remission rate (30.8% versus 2.6%, p = 0.003) were both significantly higher in the non-PLA(2)R-associated group than in the PLA(2)R-associated group at the 3rd month visit point, and at the 6th month time point, the complete remission rate was still significantly higher in the non-PLA(2)R-associated group (46.2% versus 11.5%,p = 0.007). But similar remission rates were found after the 9th month. Relapses were observed in 8 patients in PLA(2)R-associated group and none in non-PLA(2)R-associated group, although there was no significant difference between these two groups. CONCLUSION: Compared with the PLA(2)R-associated IMN, the non-PLA(2)R-associated IMN responded quicker to the immunosuppressive therapy. Twit Text FOAVip Response to immunosuppressive therapy in PLA(2)R- associated and non-PLA(2)R- associated idiopathic membranous nephropathy: a retrospective, multicenter cohort study ????BMC Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=28693446 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28693446 #FOAvip English Wikipedia <ref>{{Cite pmid|28693446 }}</ref> Response to immunosuppressive therapy in PLA(2)R- associated and non-PLA(2)R- associated idiopathic membranous nephropathy: a retrospective, multicenter cohort study #MMPMID28693446 Wang J ; Xie Q ; Sun Z ; Xu N ; Li Y ; Wang L ; Liu S ; Xue J ; Hao CM BMC Nephrol 2017[Jul]; 18 (1 ): 227 PMID28693446 show ga BACKGROUND: According to renal M type phospholipase A(2) receptor (PLA(2)R) immunohistochemistry, idiopathic membranous nephropathy (IMN) could be categorized into PLA(2)R-associated and non-PLA(2)R-associated IMN. We conducted a retrospective, multicenter cohort study with 91 patients to compare the effect of immunosuppressive therapy between PLA(2)R-associated and non-PLA(2)R-associated IMN patients. METHODS: A total of 91 biopsy-proven IMN patients from Huashan hospital and People's Hospital of Wuxi in past 5 years were collected into this study. IMN with positive PLA(2)R immunohistochemistry in kidney biopsies were designated as PLA(2)R-associated IMN. Seventy-eight of the 91 IMN patients was PLA(2)R-associated IMN and 13 were non-PLA(2)R-associated IMN. Forty-five patients were treated with prednisone plus cyclophosphamide (CTX), and 46 with prednisone plus calcineurin inhibitors (CNIs). The follow-up duration was 15 months. RESULTS: The total remission rate (76.9% versus 44.9%, p = 0.032) and complete remission rate (30.8% versus 2.6%, p = 0.003) were both significantly higher in the non-PLA(2)R-associated group than in the PLA(2)R-associated group at the 3rd month visit point, and at the 6th month time point, the complete remission rate was still significantly higher in the non-PLA(2)R-associated group (46.2% versus 11.5%,p = 0.007). But similar remission rates were found after the 9th month. Relapses were observed in 8 patients in PLA(2)R-associated group and none in non-PLA(2)R-associated group, although there was no significant difference between these two groups. CONCLUSION: Compared with the PLA(2)R-associated IMN, the non-PLA(2)R-associated IMN responded quicker to the immunosuppressive therapy. |Adult [MESH] |Aged [MESH] |Cohort Studies [MESH] |Female [MESH] |Follow-Up Studies [MESH] |Glomerulonephritis, Membranous/*diagnosis/*drug therapy [MESH] |Humans [MESH] |Immunosuppressive Agents/pharmacology/*therapeutic use [MESH] |Kidney/*chemistry/drug effects [MESH] |Male [MESH] |Middle Aged [MESH] |Receptors, Phospholipase A2/*analysis [MESH] |Retrospective Studies [MESH]Response to immunosuppressive therapy in PLA(2)R- associated and non-P(epmc).pdf DeepDyve Pubget Overpricing