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10.1186/s13054-017-1763-5 http://scihub22266oqcxt.onion/10.1186/s13054-017-1763-5 C5504626!5504626!28693606     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Crit+Care 2017 ; 21 (ä): ä Nephropedia Template TP {{tp|p=28693606|t=2017. Combined use of serum (1,3)-?-d-glucan and procalcitonin for the early differential diagnosis between candidaemia and bacteraemia in intensive care units |pdf=|usr=}}{{28693606}} gab.com Text Combined use of serum (1,3)- -d-glucan and procalcitonin for the early differential diagnosis between candidaemia and bacteraemia in intensive care units JO: Crit Care http://www.kidney.de/pget.php?&tw=1&pmid=28693606 #FOAvip Background: This study aimed to assess the combined performance of serum (1,3)-?-d-glucan (BDG) and procalcitonin (PCT) for the differential diagnosis between candidaemia and bacteraemia in three intensive care units (ICUs) in two large teaching hospitals in Italy. Methods: From June 2014 to December 2015, all adult patients admitted to the ICU who had a culture-proven candidaemia or bacteraemia, as well as BDG and PCT measured closely to the time of the index culture, were included in the study. The diagnostic performance of BDG and PCT, used either separately or in combination, was assessed by calculating the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and positive and negative likelihood ratios (LR+ and LR?). Changes from pre-test probabilities to post-test probabilities of candidaemia and bacteraemia were inferred from Fagan?s nomograms. Results: One hundred and sixty-six patients were included, 73 with candidaemia (44%) and 93 with bacteraemia (56%). When both markers indicated candidaemia (BDG ?80 pg/ml and PCT <2 ng/ml) they showed higher PPV (96%) compared to 79% and 66% for BDG or PCT alone, respectively. When both markers indicated bacteraemia (BDG <80 pg/ml and PCT ?2 ng/ml), their NPV for candidaemia was similar to that of BDG used alone (95% vs. 93%). Discordant BDG and PCT results (i.e. one indicating candidaemia and the other bacteraemia) only slightly altered the pre-test probabilities of the two diseases. Conclusions: The combined use of PCT and BDG could be helpful in the diagnostic workflow for critically ill patients with suspected candidaemia. Electronic supplementary material: The online version of this article (doi:10.1186/s13054-017-1763-5) contains supplementary material, which is available to authorized users. Twit Text FOAVip Combined use of serum (1,3)- -d-glucan and procalcitonin for the early differential diagnosis between candidaemia and bacteraemia in intensive care units ????Crit Care http://www.kidney.de/pget.php?&tw=1&pmid=28693606 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28693606 #FOAvip English Wikipedia <ref>{{Cite pmid|28693606}}</ref> Combined use of serum (1,3)-?-d-glucan and procalcitonin for the early differential diagnosis between candidaemia and bacteraemia in intensive care units #MMPMID28693606 Giacobbe DR; Mikulska M; Tumbarello M; Furfaro E; Spadaro M; Losito AR; Mesini A; De Pascale G; Marchese A; Bruzzone M; Pelosi P; Mussap M; Molin A; Antonelli M; Posteraro B; Sanguinetti M; Viscoli C; Del Bono V Crit Care 2017[]; 21 (ä): ä PMID28693606show ga Background: This study aimed to assess the combined performance of serum (1,3)-?-d-glucan (BDG) and procalcitonin (PCT) for the differential diagnosis between candidaemia and bacteraemia in three intensive care units (ICUs) in two large teaching hospitals in Italy. Methods: From June 2014 to December 2015, all adult patients admitted to the ICU who had a culture-proven candidaemia or bacteraemia, as well as BDG and PCT measured closely to the time of the index culture, were included in the study. The diagnostic performance of BDG and PCT, used either separately or in combination, was assessed by calculating the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and positive and negative likelihood ratios (LR+ and LR?). Changes from pre-test probabilities to post-test probabilities of candidaemia and bacteraemia were inferred from Fagan?s nomograms. Results: One hundred and sixty-six patients were included, 73 with candidaemia (44%) and 93 with bacteraemia (56%). When both markers indicated candidaemia (BDG ?80 pg/ml and PCT <2 ng/ml) they showed higher PPV (96%) compared to 79% and 66% for BDG or PCT alone, respectively. When both markers indicated bacteraemia (BDG <80 pg/ml and PCT ?2 ng/ml), their NPV for candidaemia was similar to that of BDG used alone (95% vs. 93%). Discordant BDG and PCT results (i.e. one indicating candidaemia and the other bacteraemia) only slightly altered the pre-test probabilities of the two diseases. Conclusions: The combined use of PCT and BDG could be helpful in the diagnostic workflow for critically ill patients with suspected candidaemia. Electronic supplementary material: The online version of this article (doi:10.1186/s13054-017-1763-5) contains supplementary material, which is available to authorized users. äCombined use of serum (1,3)-?-d-glucan and procalcitonin for the early(epmc).pdf DeepDyve Pubget Overpricing