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10.1152/ajpheart.00401.2013 http://scihub22266oqcxt.onion/10.1152/ajpheart.00401.2013 C5504390!5504390 !23873796     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23873796 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Physiol+Heart+Circ+Physiol 2013 ; 305 (7 ): H1068-79 Nephropedia Template TP {{tp|p=23873796 |t=2013. Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat |pdf=|usr=}}{{23873796 }} gab.com Text Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat JO: Am J Physiol Heart Circ Physiol http://www.kidney.de/pget.php?&tw=1&pmid=23873796 #FOAvip The treatment of heart failure (HF) is challenging and morbidity and mortality are high. The goal of this study was to determine if inhibition of the late Na(+) current with ranolazine during early hypertensive heart disease might slow or stop disease progression. Spontaneously hypertensive rats (aged 7 mo) were subjected to echocardiographic study and then fed either control chow (CON) or chow containing 0.5% ranolazine (RAN) for 3 mo. Animals were then restudied, and each heart was removed for measurements of t-tubule organization and Ca(2+) transients using confocal microscopy of the intact heart. RAN halted left ventricular hypertrophy as determined from both echocardiographic and cell dimension (length but not width) measurements. RAN reduced the number of myocytes with t-tubule disruption and the proportion of myocytes with defects in intracellular Ca(2+) cycling. RAN also prevented the slowing of the rate of restitution of Ca(2+) release and the increased vulnerability to rate-induced Ca(2+) alternans. Differences between CON- and RAN-treated animals were not a result of different expression levels of voltage-dependent Ca(2+) channel 1.2, sarco(endo)plasmic reticulum Ca(2+)-ATPase 2a, ryanodine receptor type 2, Na(+)/Ca(2+) exchanger-1, or voltage-gated Na(+) channel 1.5. Furthermore, myocytes with defective Ca(2+) transients in CON rats showed improved Ca(2+) cycling immediately upon acute exposure to RAN. Increased late Na(+) current likely plays a role in the progression of cardiac hypertrophy, a key pathological step in the development of HF. Early, chronic inhibition of this current slows both hypertrophy and development of ultrastructural and physiological defects associated with the progression to HF. Twit Text FOAVip Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat ????Am J Physiol Heart Circ Physiol http://www.kidney.de/pget.php?&tw=1&pmid=23873796 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23873796 #FOAvip English Wikipedia <ref>{{Cite pmid|23873796 }}</ref> Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat #MMPMID23873796 Aistrup GL ; Gupta DK ; Kelly JE ; O'Toole MJ ; Nahhas A ; Chirayil N ; Misener S ; Beussink L ; Singh N ; Ng J ; Reddy M ; Mongkolrattanothai T ; El-Bizri N ; Rajamani S ; Shryock JC ; Belardinelli L ; Shah SJ ; Wasserstrom JA Am J Physiol Heart Circ Physiol 2013[Oct]; 305 (7 ): H1068-79 PMID23873796 show ga The treatment of heart failure (HF) is challenging and morbidity and mortality are high. The goal of this study was to determine if inhibition of the late Na(+) current with ranolazine during early hypertensive heart disease might slow or stop disease progression. Spontaneously hypertensive rats (aged 7 mo) were subjected to echocardiographic study and then fed either control chow (CON) or chow containing 0.5% ranolazine (RAN) for 3 mo. Animals were then restudied, and each heart was removed for measurements of t-tubule organization and Ca(2+) transients using confocal microscopy of the intact heart. RAN halted left ventricular hypertrophy as determined from both echocardiographic and cell dimension (length but not width) measurements. RAN reduced the number of myocytes with t-tubule disruption and the proportion of myocytes with defects in intracellular Ca(2+) cycling. RAN also prevented the slowing of the rate of restitution of Ca(2+) release and the increased vulnerability to rate-induced Ca(2+) alternans. Differences between CON- and RAN-treated animals were not a result of different expression levels of voltage-dependent Ca(2+) channel 1.2, sarco(endo)plasmic reticulum Ca(2+)-ATPase 2a, ryanodine receptor type 2, Na(+)/Ca(2+) exchanger-1, or voltage-gated Na(+) channel 1.5. Furthermore, myocytes with defective Ca(2+) transients in CON rats showed improved Ca(2+) cycling immediately upon acute exposure to RAN. Increased late Na(+) current likely plays a role in the progression of cardiac hypertrophy, a key pathological step in the development of HF. Early, chronic inhibition of this current slows both hypertrophy and development of ultrastructural and physiological defects associated with the progression to HF. |Acetanilides/*pharmacology [MESH] |Animals [MESH] |Calcium Channels, L-Type/drug effects/metabolism [MESH] |Calcium Signaling/*drug effects [MESH] |Disease Models, Animal [MESH] |Disease Progression [MESH] |Dose-Response Relationship, Drug [MESH] |Heart Failure/etiology/metabolism/physiopathology/prevention & control [MESH] |Hypertension/complications/diagnostic imaging/*drug therapy/metabolism/physiopathology [MESH] |Hypertrophy, Left Ventricular/etiology/metabolism/physiopathology/prevention & control [MESH] |Male [MESH] |Myocytes, Cardiac/*drug effects/metabolism [MESH] |NAV1.5 Voltage-Gated Sodium Channel/drug effects/metabolism [MESH] |Piperazines/*pharmacology [MESH] |Ranolazine [MESH] |Rats [MESH] |Rats, Inbred SHR [MESH] |Ryanodine Receptor Calcium Release Channel/drug effects/metabolism [MESH] |Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism [MESH] |Sodium Channel Blockers/*pharmacology [MESH] |Sodium Channels/*drug effects/metabolism [MESH] |Sodium-Calcium Exchanger/drug effects/metabolism [MESH] |Sodium/*metabolism [MESH] |Time Factors [MESH]Inhibition of the late sodium current slows t-tubule disruption during(epmc).pdf DeepDyve Pubget Overpricing