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10.1038/ncomms16043 http://scihub22266oqcxt.onion/10.1038/ncomms16043 C5504353!5504353 !28685753     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28685753 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (ä): 16043 Nephropedia Template TP {{tp|p=28685753 |t=2017. Nucleolin directly mediates Epstein-Barr virus immune evasion through binding to G-quadruplexes of EBNA1 mRNA |pdf=|usr=}}{{28685753 }} gab.com Text Nucleolin directly mediates Epstein-Barr virus immune evasion through binding to G-quadruplexes of EBNA1 mRNA JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28685753 #FOAvip The oncogenic Epstein-Barr virus (EBV) evades the immune system but has an Achilles heel: its genome maintenance protein EBNA1, which is essential for viral genome maintenance but highly antigenic. EBV has seemingly evolved a system in which the mRNA sequence encoding the glycine-alanine repeats (GAr) of the EBNA1 protein limits its expression to the minimal level necessary for function while minimizing immune recognition. Here, we identify nucleolin (NCL) as a host factor required for this process via a direct interaction with G-quadruplexes formed in GAr-encoding mRNA sequence. Overexpression of NCL enhances GAr-based inhibition of EBNA1 protein expression, whereas its downregulation relieves the suppression of both expression and antigen presentation. Moreover, the G-quadruplex ligand PhenDC3 prevents NCL binding to EBNA1 mRNA and reverses GAr-mediated repression of EBNA1 expression and antigen presentation. Hence the NCL-EBNA1 mRNA interaction is a relevant therapeutic target to trigger an immune response against EBV-carrying cancers. Twit Text FOAVip Nucleolin directly mediates Epstein-Barr virus immune evasion through binding to G-quadruplexes of EBNA1 mRNA ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28685753 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28685753 #FOAvip English Wikipedia <ref>{{Cite pmid|28685753 }}</ref> Nucleolin directly mediates Epstein-Barr virus immune evasion through binding to G-quadruplexes of EBNA1 mRNA #MMPMID28685753 Lista MJ ; Martins RP ; Billant O ; Contesse MA ; Findakly S ; Pochard P ; Daskalogianni C ; Beauvineau C ; Guetta C ; Jamin C ; Teulade-Fichou MP ; Fåhraeus R ; Voisset C ; Blondel M Nat Commun 2017[Jul]; 8 (ä): 16043 PMID28685753 show ga The oncogenic Epstein-Barr virus (EBV) evades the immune system but has an Achilles heel: its genome maintenance protein EBNA1, which is essential for viral genome maintenance but highly antigenic. EBV has seemingly evolved a system in which the mRNA sequence encoding the glycine-alanine repeats (GAr) of the EBNA1 protein limits its expression to the minimal level necessary for function while minimizing immune recognition. Here, we identify nucleolin (NCL) as a host factor required for this process via a direct interaction with G-quadruplexes formed in GAr-encoding mRNA sequence. Overexpression of NCL enhances GAr-based inhibition of EBNA1 protein expression, whereas its downregulation relieves the suppression of both expression and antigen presentation. Moreover, the G-quadruplex ligand PhenDC3 prevents NCL binding to EBNA1 mRNA and reverses GAr-mediated repression of EBNA1 expression and antigen presentation. Hence the NCL-EBNA1 mRNA interaction is a relevant therapeutic target to trigger an immune response against EBV-carrying cancers. |*Host-Pathogen Interactions [MESH] |Aminoquinolines/pharmacology [MESH] |Animals [MESH] |B-Lymphocytes/drug effects/*immunology/virology [MESH] |Cell Line, Tumor [MESH] |Epstein-Barr Virus Nuclear Antigens/*genetics/immunology [MESH] |G-Quadruplexes [MESH] |HCT116 Cells [MESH] |Herpesvirus 4, Human/drug effects/*genetics/immunology [MESH] |Humans [MESH] |Immune Evasion/*genetics [MESH] |Leontopithecus [MESH] |Ligands [MESH] |Nucleolin [MESH] |Phosphoproteins/*genetics/immunology [MESH] |Picolinic Acids/pharmacology [MESH] |Quinolines/pharmacology [MESH] |RNA, Messenger/*genetics/immunology [MESH] |RNA-Binding Proteins/*genetics/immunology [MESH]Nucleolin directly mediates Epstein-Barr virus immune evasion through (epmc).pdf DeepDyve Pubget Overpricing