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10.1038/s41598-017-04773-8 http://scihub22266oqcxt.onion/10.1038/s41598-017-04773-8 C5504060!5504060 !28694452     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28694452 &cmd=llinks): Failed to open stream: HTTP request failed! 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Phosphatidylserine-mediated platelet clearance by endothelium decreases platelet aggregates and procoagulant activity in sepsis |pdf=|usr=}}{{28694452 }} gab.com Text Phosphatidylserine-mediated platelet clearance by endothelium decreases platelet aggregates and procoagulant activity in sepsis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28694452 #FOAvip The mechanisms that eliminate activated platelets in inflammation-induced disseminated intravascular coagulation (DIC) in micro-capillary circulation are poorly understood. This study explored an alternate pathway for platelet disposal mediated by endothelial cells (ECs) through phosphatidylserine (PS) and examined the effect of platelet clearance on procoagulant activity (PCA) in sepsis. Platelets in septic patients demonstrated increased levels of surface activation markers and apoptotic vesicle formation, and also formed aggregates with leukocytes. Activated platelets adhered were and ultimately digested by ECs in vivo and in vitro. Blocking PS on platelets or ?v?3 integrin on ECs attenuated platelet clearance resulting in increased platelet count in a mouse model of sepsis. Furthermore, platelet removal by ECs resulted in a corresponding decrease in platelet-leukocyte complex formation and markedly reduced generation of factor Xa and thrombin on platelets. Pretreatment with lactadherin significantly increased phagocytosis of platelets by approximately 2-fold, diminished PCA by 70%, prolonged coagulation time, and attenuated fibrin formation by 50%. Our results suggest that PS-mediated clearance of activated platelets by the endothelium results in an anti-inflammatory, anticoagulant, and antithrombotic effect that contribute to maintaining platelet homeostasis during acute inflammation. These results suggest a new therapeutic target for impeding the development of DIC. Twit Text FOAVip Phosphatidylserine-mediated platelet clearance by endothelium decreases platelet aggregates and procoagulant activity in sepsis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28694452 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28694452 #FOAvip English Wikipedia <ref>{{Cite pmid|28694452 }}</ref> Phosphatidylserine-mediated platelet clearance by endothelium decreases platelet aggregates and procoagulant activity in sepsis #MMPMID28694452 Ma R ; Xie R ; Yu C ; Si Y ; Wu X ; Zhao L ; Yao Z ; Fang S ; Chen H ; Novakovic V ; Gao C ; Kou J ; Bi Y ; Thatte HS ; Yu B ; Yang S ; Zhou J ; Shi J Sci Rep 2017[Jul]; 7 (1 ): 4978 PMID28694452 show ga The mechanisms that eliminate activated platelets in inflammation-induced disseminated intravascular coagulation (DIC) in micro-capillary circulation are poorly understood. This study explored an alternate pathway for platelet disposal mediated by endothelial cells (ECs) through phosphatidylserine (PS) and examined the effect of platelet clearance on procoagulant activity (PCA) in sepsis. Platelets in septic patients demonstrated increased levels of surface activation markers and apoptotic vesicle formation, and also formed aggregates with leukocytes. Activated platelets adhered were and ultimately digested by ECs in vivo and in vitro. Blocking PS on platelets or ?v?3 integrin on ECs attenuated platelet clearance resulting in increased platelet count in a mouse model of sepsis. Furthermore, platelet removal by ECs resulted in a corresponding decrease in platelet-leukocyte complex formation and markedly reduced generation of factor Xa and thrombin on platelets. Pretreatment with lactadherin significantly increased phagocytosis of platelets by approximately 2-fold, diminished PCA by 70%, prolonged coagulation time, and attenuated fibrin formation by 50%. Our results suggest that PS-mediated clearance of activated platelets by the endothelium results in an anti-inflammatory, anticoagulant, and antithrombotic effect that contribute to maintaining platelet homeostasis during acute inflammation. These results suggest a new therapeutic target for impeding the development of DIC. |Adult [MESH] |Blood Coagulation [MESH] |Blood Platelets/*cytology/drug effects/metabolism [MESH] |Cell-Derived Microparticles/metabolism [MESH] |Endothelial Cells/*cytology/metabolism [MESH] |Endothelium, Vascular/metabolism [MESH] |Female [MESH] |Human Umbilical Vein Endothelial Cells [MESH] |Humans [MESH] |Leukocytes/cytology/drug effects/metabolism [MESH] |Male [MESH] |Middle Aged [MESH] |Phosphatidylserines/*pharmacology [MESH] |Platelet Activation/*drug effects [MESH]Phosphatidylserine-mediated platelet clearance by endothelium decrease(epmc).pdf DeepDyve Pubget Overpricing