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10.1038/s41598-017-05226-y http://scihub22266oqcxt.onion/10.1038/s41598-017-05226-y C5503987!5503987!28694529     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28694529|t=2017. The production of fibroblast growth factor 23 is controlled by TGF-?2 |pdf=|usr=}}{{28694529}} gab.com Text The production of fibroblast growth factor 23 is controlled by TGF- 2 JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28694529 #FOAvip Transforming growth factor-? (TGF-?) is a cytokine produced by many cell types and implicated in cell growth, differentiation, apoptosis, and inflammation. It stimulates store-operated calcium entry (SOCE) through the calcium release-activated calcium (CRAC) channel Orai1/Stim1 in endometrial Ishikawa cells. Bone cells generate fibroblast growth factor (FGF) 23, which inhibits renal phosphate reabsorption and 1,25(OH)2D3 formation in concert with its co-receptor Klotho. Moreover, Klotho and FGF23 counteract aging and age-related clinical conditions. FGF23 production is dependent on Orai1-mediated SOCE and inflammation. Here, we explored a putative role of TGF-?2 in FGF23 synthesis. To this end, UMR106 osteoblast-like cells were cultured, Fgf23 transcript levels determined by qRT-PCR, FGF23 protein measured by ELISA, and SOCE analyzed by fluorescence optics. UMR106 cells expressed TGF-? receptors 1 and 2. TGF-?2 enhanced SOCE and potently stimulated the production of FGF23, an effect significantly attenuated by SB431542, an inhibitor of the transforming growth factor-? (TGF-?) type I receptor activin receptor-like kinases ALK5, ALK4, and ALK7. Furthermore, the TGF-?2 effect on FGF23 production was blunted by SOCE inhibitor 2-APB. We conclude that TGF-?2 induces FGF23 production, an effect involving up-regulation of SOCE. Twit Text FOAVip The production of fibroblast growth factor 23 is controlled by TGF- 2 ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28694529 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28694529 #FOAvip English Wikipedia <ref>{{Cite pmid|28694529}}</ref> The production of fibroblast growth factor 23 is controlled by TGF-?2 #MMPMID28694529 Feger M; Hase P; Zhang B; Hirche F; Glosse P; Lang F; Föller M Sci Rep 2017[]; 7 (ä): ä PMID28694529show ga Transforming growth factor-? (TGF-?) is a cytokine produced by many cell types and implicated in cell growth, differentiation, apoptosis, and inflammation. It stimulates store-operated calcium entry (SOCE) through the calcium release-activated calcium (CRAC) channel Orai1/Stim1 in endometrial Ishikawa cells. Bone cells generate fibroblast growth factor (FGF) 23, which inhibits renal phosphate reabsorption and 1,25(OH)2D3 formation in concert with its co-receptor Klotho. Moreover, Klotho and FGF23 counteract aging and age-related clinical conditions. FGF23 production is dependent on Orai1-mediated SOCE and inflammation. Here, we explored a putative role of TGF-?2 in FGF23 synthesis. To this end, UMR106 osteoblast-like cells were cultured, Fgf23 transcript levels determined by qRT-PCR, FGF23 protein measured by ELISA, and SOCE analyzed by fluorescence optics. UMR106 cells expressed TGF-? receptors 1 and 2. TGF-?2 enhanced SOCE and potently stimulated the production of FGF23, an effect significantly attenuated by SB431542, an inhibitor of the transforming growth factor-? (TGF-?) type I receptor activin receptor-like kinases ALK5, ALK4, and ALK7. Furthermore, the TGF-?2 effect on FGF23 production was blunted by SOCE inhibitor 2-APB. We conclude that TGF-?2 induces FGF23 production, an effect involving up-regulation of SOCE. äThe production of fibroblast growth factor 23 is controlled by TGF-?2 (epmc).pdf DeepDyve Pubget Overpricing