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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Blood+Res 2017 ; 52 (2): 95-9 Nephropedia Template TP
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Dapsone therapy for refractory immune thrombocytopenia patients: a case series #MMPMID28698844
Lee JY; Lee JO; Jung JY; Bang SM
Blood Res 2017[Jun]; 52 (2): 95-9 PMID28698844show ga
Background: Dapsone has been recommended as a second-line immunosuppressive agent for patients with immune thrombocytopenia (ITP). Methods: We retrospectively analyzed the efficacy and safety of dapsone therapy in patients with ITP. Results: Nine ITP patients were treated with dapsone at a dose of 50?100 mg/day between May 2013 and March 2016. All patients were refractory to multiple previous treatments, with a median of 7 agents (range, 4?8), and 3 patients had undergone a previous splenectomy. The median pre-treatment platelet count was 4×109/L (range, 3?27×109/L). Only 1 patient (11.1%) responded to dapsone therapy. No severe adverse events were observed, except for 1 case of dapsone hypersensitivity syndrome. Conclusion: Although dapsone is still useful for some patients, it may be ineffective in heavily pretreated patients with profound thrombocytopenia.