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10.1016/j.jaip.2016.12.027 http://scihub22266oqcxt.onion/10.1016/j.jaip.2016.12.027 C5503772!5503772 !28286156     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28286156 &cmd=llinks): Failed to open stream: HTTP request failed! 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Clinical Characteristics of Patients with Chronic Rhinosinusitis with Nasal Polyps, Asthma, and Aspirin-Exacerbated Respiratory Disease |pdf=|usr=}}{{28286156 }} gab.com Text Clinical Characteristics of Patients with Chronic Rhinosinusitis with Nasal Polyps, Asthma, and Aspirin-Exacerbated Respiratory Disease JO: J Allergy Clin Immunol Pract http://www.kidney.de/pget.php?&tw=1&pmid=28286156 #FOAvip BACKGROUND: Aspirin-exacerbated respiratory disease (AERD) comprises the triad of chronic rhinosinusitis with nasal polyps (CRSwNP), asthma, and intolerance to inhibitors of the cyclooxygenase-1 (COX-1) enzyme. The prevalence of AERD remains unclear, and few studies have compared the clinical characteristics of patients with AERD to those with CRSwNP alone, asthma alone, or both CRSwNP and asthma. OBJECTIVE: To determine the prevalence of AERD within a tertiary care setting, and to identify unique clinical features that could distinguish these patients from those with both CRSwNP and asthma or with CRSwNP alone. METHODS: Electronic medical records of patients at Northwestern in Chicago, Illinois, were searched by computer algorithm and then manual chart review to identify 459 patients with CRSwNP alone, 412 with both CRSwNP and asthma, 171 with AERD, and 300 with asthma only. Demographic and clinical features including sex, atopy, and sinus disease severity were characterized. RESULTS: The prevalence of AERD among patients with CRSwNP was 16%. Patients with AERD had undergone 2-fold more sinus surgeries (P < .001) and were significantly younger at the time of their first surgery (40 ± 13 years) than were patients with CRSwNP (43 ± 14 years; P < .05). Atopy was significantly more prevalent in patients with AERD (84%) or asthma (85%) than in patients with CRSwNP (66%, P < .05). More patients with AERD (13%) had corticosteroid-dependent disease than patients with both CRSwNP and asthma (4%, P < .01) or asthma (1%, P < .001). CONCLUSIONS: AERD is common among patients with CRSwNP; even though patients with AERD have CRSwNP and asthma, the clinical course of their disease is not the same as of patients who have CRSwNP and asthma but are tolerant to COX-1 inhibitors. Twit Text FOAVip Clinical Characteristics of Patients with Chronic Rhinosinusitis with Nasal Polyps, Asthma, and Aspirin-Exacerbated Respiratory Disease ????J Allergy Clin Immunol Pract http://www.kidney.de/pget.php?&tw=1&pmid=28286156 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28286156 #FOAvip English Wikipedia <ref>{{Cite pmid|28286156 }}</ref> Clinical Characteristics of Patients with Chronic Rhinosinusitis with Nasal Polyps, Asthma, and Aspirin-Exacerbated Respiratory Disease #MMPMID28286156 Stevens WW ; Peters AT ; Hirsch AG ; Nordberg CM ; Schwartz BS ; Mercer DG ; Mahdavinia M ; Grammer LC ; Hulse KE ; Kern RC ; Avila P ; Schleimer RP J Allergy Clin Immunol Pract 2017[Jul]; 5 (4 ): 1061-1070.e3 PMID28286156 show ga BACKGROUND: Aspirin-exacerbated respiratory disease (AERD) comprises the triad of chronic rhinosinusitis with nasal polyps (CRSwNP), asthma, and intolerance to inhibitors of the cyclooxygenase-1 (COX-1) enzyme. The prevalence of AERD remains unclear, and few studies have compared the clinical characteristics of patients with AERD to those with CRSwNP alone, asthma alone, or both CRSwNP and asthma. OBJECTIVE: To determine the prevalence of AERD within a tertiary care setting, and to identify unique clinical features that could distinguish these patients from those with both CRSwNP and asthma or with CRSwNP alone. METHODS: Electronic medical records of patients at Northwestern in Chicago, Illinois, were searched by computer algorithm and then manual chart review to identify 459 patients with CRSwNP alone, 412 with both CRSwNP and asthma, 171 with AERD, and 300 with asthma only. Demographic and clinical features including sex, atopy, and sinus disease severity were characterized. RESULTS: The prevalence of AERD among patients with CRSwNP was 16%. Patients with AERD had undergone 2-fold more sinus surgeries (P < .001) and were significantly younger at the time of their first surgery (40 ± 13 years) than were patients with CRSwNP (43 ± 14 years; P < .05). Atopy was significantly more prevalent in patients with AERD (84%) or asthma (85%) than in patients with CRSwNP (66%, P < .05). More patients with AERD (13%) had corticosteroid-dependent disease than patients with both CRSwNP and asthma (4%, P < .01) or asthma (1%, P < .001). CONCLUSIONS: AERD is common among patients with CRSwNP; even though patients with AERD have CRSwNP and asthma, the clinical course of their disease is not the same as of patients who have CRSwNP and asthma but are tolerant to COX-1 inhibitors. |Adult [MESH] |Aged [MESH] |Aspirin/adverse effects/therapeutic use [MESH] |Asthma, Aspirin-Induced/diagnosis/*epidemiology/physiopathology/therapy [MESH] |Asthma/*epidemiology/physiopathology [MESH] |Chronic Disease [MESH] |Comorbidity [MESH] |Cyclooxygenase Inhibitors/adverse effects/therapeutic use [MESH] |Female [MESH] |Humans [MESH] |Illinois/epidemiology [MESH] |Male [MESH] |Middle Aged [MESH] |Nasal Polyps/*epidemiology/physiopathology [MESH] |Prevalence [MESH] |Respiratory Function Tests [MESH] |Rhinitis/diagnostic imaging/*epidemiology/physiopathology [MESH] |Sinusitis/diagnostic imaging/*epidemiology/physiopathology [MESH]Clinical Characteristics of Patients with Chronic Rhinosinusitis with (epmc).pdf DeepDyve Pubget Overpricing