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10.1016/j.cell.2016.03.046 http://scihub22266oqcxt.onion/10.1016/j.cell.2016.03.046 C5503689!5503689!27153493     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2016 ; 165 (4): 792-800 Nephropedia Template TP {{tp|p=27153493|t=2016. Inflammasome complexes: emerging mechanisms and effector functions |pdf=|usr=}}{{27153493}} gab.com Text Inflammasome complexes: emerging mechanisms and effector functions JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=27153493 #FOAvip Canonical activation of the inflammasome is critical to promote caspase-1-dependent maturation of the proinflammatory cytokines IL-1? and IL-18, as well as to induce pyroptotic cell death in response to pathogens and endogenous danger signals. Recent discoveries, however, are beginning to unveil new components of the inflammasome machinery, and the full spectrum of inflammasome functions, extending their influence beyond canonical functions, to regulation of eicosanoid storm, autophagy and metabolism. In addition, the receptor components of the inflammasome can also regulate diverse biological processes, such as cellular proliferation, gene transcription and tumorigenesis, all of which are independent of their inflammasome complex-forming capabilities. Here, we review these recent advances that are shaping our understanding of the complex biology of the inflammasome and its constituents. Twit Text FOAVip Inflammasome complexes: emerging mechanisms and effector functions ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=27153493 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27153493 #FOAvip English Wikipedia <ref>{{Cite pmid|27153493}}</ref> Inflammasome complexes: emerging mechanisms and effector functions #MMPMID27153493 Rathinam VAK; Fitzgerald KA Cell 2016[May]; 165 (4): 792-800 PMID27153493show ga Canonical activation of the inflammasome is critical to promote caspase-1-dependent maturation of the proinflammatory cytokines IL-1? and IL-18, as well as to induce pyroptotic cell death in response to pathogens and endogenous danger signals. Recent discoveries, however, are beginning to unveil new components of the inflammasome machinery, and the full spectrum of inflammasome functions, extending their influence beyond canonical functions, to regulation of eicosanoid storm, autophagy and metabolism. In addition, the receptor components of the inflammasome can also regulate diverse biological processes, such as cellular proliferation, gene transcription and tumorigenesis, all of which are independent of their inflammasome complex-forming capabilities. Here, we review these recent advances that are shaping our understanding of the complex biology of the inflammasome and its constituents. äInflammasome complexes: emerging mechanisms and effector functions (epmc).pdf DeepDyve Pubget Overpricing