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2017 ; 8
(24
): 39774-39781
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Comparison between proton boron fusion therapy (PBFT) and boron neutron capture
therapy (BNCT): a monte carlo study
#MMPMID28427153
Jung JY
; Yoon DK
; Barraclough B
; Lee HC
; Suh TS
; Lu B
Oncotarget
2017[Jun]; 8
(24
): 39774-39781
PMID28427153
show ga
The aim of this study is to compare between proton boron fusion therapy (PBFT)
and boron neutron capture therapy (BNCT) and to analyze dose escalation using a
Monte Carlo simulation. We simulated a proton beam passing through the water with
a boron uptake region (BUR) in MCNPX. To estimate the interaction between
neutrons/protons and borons by the alpha particle, the simulation yielded with a
variation of the center of the BUR location and proton energies. The variation
and influence about the alpha particle were observed from the percent depth dose
(PDD) and cross-plane dose profile of both the neutron and proton beams. The peak
value of the maximum dose level when the boron particle was accurately labeled at
the region was 192.4% among the energies. In all, we confirmed that prompt gamma
rays of 478 keV and 719 keV were generated by the nuclear reactions in PBFT and
BNCT, respectively. We validated the dramatic effectiveness of the alpha
particle, especially in PBFT. The utility of PBFT was verified using the
simulation and it has a potential for application in radiotherapy.