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10.18632/oncotarget.17135 http://scihub22266oqcxt.onion/10.18632/oncotarget.17135 C5503631!5503631 !28465474     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28465474 &cmd=llinks): Failed to open stream: HTTP request failed! 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Nanoparticle-mediated dual delivery of resveratrol and DAP5 ameliorates kidney ischemia/reperfusion injury by inhibiting cell apoptosis and inflammation |pdf=|usr=}}{{28465474 }} gab.com Text Nanoparticle-mediated dual delivery of resveratrol and DAP5 ameliorates kidney ischemia/reperfusion injury by inhibiting cell apoptosis and inflammation JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28465474 #FOAvip Ischemia reperfusion (I/R) injury is a leading cause of acute kidney injury with high morbidity and mortality due to limited therapy. NMDA receptor inhibitor (DAP5) and resveratrol (Res) could ameliorate kidney I/R injury, but their use is limited by low aqueous solubility and poor stability. Here, we examined the potential protective effects of Res-DAP5 nanoparticles (NP) against renal I/R injury. Mice were subjected to renal ischemia for 30 min followed by reperfusion for 24 h. The results showed that Res-DAP5-NP could decreased serum creatinine (Cr) and urea nitrogen (BUN), alleviated tubular damage and oxidative stress. In addition, Res-DAP5-NP suppressed cell apoptosis, promoted the expression of p-DAPK, and inhibited the expression of p-CaMK and p-AKT. Furthermore, Res-DAP5-NP decreased the production of pro-inflammatory cytokines such as tumor necrosis factor-?, IL-1?, IL-6, and p-I?B? induced by renal I/R injury. In addition, Res-DAP5-NP also attenuated renal I/R injury in vivo, as manifested by increase in cell viability, SOD level, and the expression of p-DAPK, decreases in intracellular Ca2+ concentration and the expression of p-CaMK. Taken together, our findings indicates that Res-DAP5-NP could effectively protect renal I/R injury by inhibiting apoptosis and inflammation responses, possibly through AKT/NMDA/CaMK/DAPK and NF-?B pathways. Twit Text FOAVip Nanoparticle-mediated dual delivery of resveratrol and DAP5 ameliorates kidney ischemia/reperfusion injury by inhibiting cell apoptosis and inflammation ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28465474 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28465474 #FOAvip English Wikipedia <ref>{{Cite pmid|28465474 }}</ref> Nanoparticle-mediated dual delivery of resveratrol and DAP5 ameliorates kidney ischemia/reperfusion injury by inhibiting cell apoptosis and inflammation #MMPMID28465474 Xu Y ; Zhang B ; Xie D ; Hu Y ; Li HL ; Zhong LL ; Wang HW ; Jiang W ; Ke ZP ; Zheng DH Oncotarget 2017[Jun]; 8 (24 ): 39547-39558 PMID28465474 show ga Ischemia reperfusion (I/R) injury is a leading cause of acute kidney injury with high morbidity and mortality due to limited therapy. NMDA receptor inhibitor (DAP5) and resveratrol (Res) could ameliorate kidney I/R injury, but their use is limited by low aqueous solubility and poor stability. Here, we examined the potential protective effects of Res-DAP5 nanoparticles (NP) against renal I/R injury. Mice were subjected to renal ischemia for 30 min followed by reperfusion for 24 h. The results showed that Res-DAP5-NP could decreased serum creatinine (Cr) and urea nitrogen (BUN), alleviated tubular damage and oxidative stress. In addition, Res-DAP5-NP suppressed cell apoptosis, promoted the expression of p-DAPK, and inhibited the expression of p-CaMK and p-AKT. Furthermore, Res-DAP5-NP decreased the production of pro-inflammatory cytokines such as tumor necrosis factor-?, IL-1?, IL-6, and p-I?B? induced by renal I/R injury. In addition, Res-DAP5-NP also attenuated renal I/R injury in vivo, as manifested by increase in cell viability, SOD level, and the expression of p-DAPK, decreases in intracellular Ca2+ concentration and the expression of p-CaMK. Taken together, our findings indicates that Res-DAP5-NP could effectively protect renal I/R injury by inhibiting apoptosis and inflammation responses, possibly through AKT/NMDA/CaMK/DAPK and NF-?B pathways. |*Drug Delivery Systems [MESH] |*Nanoparticles [MESH] |Animals [MESH] |Apoptosis/*drug effects [MESH] |Biomarkers [MESH] |Calcium/metabolism [MESH] |Caspase 3/metabolism [MESH] |Cell Line [MESH] |Cell Survival/drug effects [MESH] |Cytokines/metabolism [MESH] |Disease Models, Animal [MESH] |Humans [MESH] |Inflammation Mediators [MESH] |Kidney Diseases/drug therapy/*metabolism/*pathology/physiopathology [MESH] |Kidney Function Tests [MESH] |Male [MESH] |Oxidative Stress/drug effects [MESH] |Protective Agents/pharmacology [MESH] |Rats [MESH] |Reactive Oxygen Species/metabolism [MESH] |Reperfusion Injury/drug therapy/*metabolism/*pathology/physiopathology [MESH] |Resveratrol [MESH]Nanoparticle-mediated dual delivery of resveratrol and DAP5 ameliorate(epmc).pdf DeepDyve Pubget Overpricing