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10.18632/oncotarget.16640 http://scihub22266oqcxt.onion/10.18632/oncotarget.16640 C5503604!5503604 !28402932     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28402932 &cmd=llinks): Failed to open stream: HTTP request failed! 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The long noncoding RNA ANRIL acts as an oncogene and contributes to paclitaxel resistance of lung adenocarcinoma A549 cells |pdf=|usr=}}{{28402932 }} gab.com Text The long noncoding RNA ANRIL acts as an oncogene and contributes to paclitaxel resistance of lung adenocarcinoma A549 cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28402932 #FOAvip Long non-coding RNAs (lncRNAs) are a family of non-protein-coding RNAs that might affect Lung adenocarcinoma (LAD) chemo-resistance and most of them could be used as biomarkers and therapy targets. However, the potential function of lncRNA ANRIL contributed paclitaxel chemo-resistance in LAD is still unknown. This study aimed to observe the expression of ANRIL in LAD, evaluate its biological role in the resistance of LAD cells to paclitaxel and explore the apoptosis role in the ANRIL associated mechanism. Our results showed that ANRIL functioning as a potential oncogene was up-regulated in LAD, and promoted the acquisition of chemo-resistance in paclitaxel partly through the mitochondrial pathway by modulating the expression of apoptosis-related protein cleaved-PARP and Bcl-2. These findings might improve LAD patients' paclitaxel treatment and made ANRIL to be a new target for paclitaxel-based chemotherapy in LAD. Twit Text FOAVip The long noncoding RNA ANRIL acts as an oncogene and contributes to paclitaxel resistance of lung adenocarcinoma A549 cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28402932 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28402932 #FOAvip English Wikipedia <ref>{{Cite pmid|28402932 }}</ref> The long noncoding RNA ANRIL acts as an oncogene and contributes to paclitaxel resistance of lung adenocarcinoma A549 cells #MMPMID28402932 Xu R ; Mao Y ; Chen K ; He W ; Shi W ; Han Y Oncotarget 2017[Jun]; 8 (24 ): 39177-39184 PMID28402932 show ga Long non-coding RNAs (lncRNAs) are a family of non-protein-coding RNAs that might affect Lung adenocarcinoma (LAD) chemo-resistance and most of them could be used as biomarkers and therapy targets. However, the potential function of lncRNA ANRIL contributed paclitaxel chemo-resistance in LAD is still unknown. This study aimed to observe the expression of ANRIL in LAD, evaluate its biological role in the resistance of LAD cells to paclitaxel and explore the apoptosis role in the ANRIL associated mechanism. Our results showed that ANRIL functioning as a potential oncogene was up-regulated in LAD, and promoted the acquisition of chemo-resistance in paclitaxel partly through the mitochondrial pathway by modulating the expression of apoptosis-related protein cleaved-PARP and Bcl-2. These findings might improve LAD patients' paclitaxel treatment and made ANRIL to be a new target for paclitaxel-based chemotherapy in LAD. |A549 Cells [MESH] |Adenocarcinoma/drug therapy/genetics/*pathology [MESH] |Antineoplastic Agents, Phytogenic/pharmacology [MESH] |Apoptosis/drug effects [MESH] |Biomarkers, Tumor [MESH] |Cell Proliferation/drug effects [MESH] |Drug Resistance, Neoplasm/*genetics [MESH] |Female [MESH] |Follow-Up Studies [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Lung Neoplasms/drug therapy/genetics/*pathology [MESH] |Male [MESH] |Oncogenes [MESH] |Paclitaxel/*pharmacology [MESH] |Prognosis [MESH] |RNA, Long Noncoding/*genetics [MESH]The long noncoding RNA ANRIL acts as an oncogene and contributes to pa(epmc).pdf DeepDyve Pubget Overpricing