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10.18632/oncotarget.16609 http://scihub22266oqcxt.onion/10.18632/oncotarget.16609 C5503601!5503601 !28388576     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28388576 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (24 ): 39143-39153 Nephropedia Template TP {{tp|p=28388576 |t=2017. Proton pump inhibitor ilaprazole suppresses cancer growth by targeting T-cell-originated protein kinase |pdf=|usr=}}{{28388576 }} gab.com Text Proton pump inhibitor ilaprazole suppresses cancer growth by targeting T-cell-originated protein kinase JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28388576 #FOAvip T-cell-originated protein kinase (TOPK) is highly and frequently expressed in various cancer tissues and plays an indispensable role in the mitosis of cancer cells, and therefore, it is an important target for drug treatment of tumor. Ilaprazole was identified to be a potent TOPK inhibitor. The data indicated that ilaprazole inhibited TOPK activities with high affinity and selectivity. In vitro studies showed that ilaprazole inhibited TOPK activities in HCT116, ES-2, A549, SW1990 cancer cells. Moreover, knockdown of TOPK in these cells decreased their sensitivities to ilaprazole. Results of an in vivo study demonstrated that gavage of ilaprazole in HCT116 colon tumor-bearing mice effectively suppressed cancer growth. The TOPK downstream signaling molecule phospho-histone H3 in tumor tissues was also decreased after ilaprazole treatment. Our results suggested that ilaprazole inhibited the cancer growth by targeting TOPK both in vitro and in vivo. Twit Text FOAVip Proton pump inhibitor ilaprazole suppresses cancer growth by targeting T-cell-originated protein kinase ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28388576 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28388576 #FOAvip English Wikipedia <ref>{{Cite pmid|28388576 }}</ref> Proton pump inhibitor ilaprazole suppresses cancer growth by targeting T-cell-originated protein kinase #MMPMID28388576 Zheng M ; Luan S ; Gao S ; Cheng L ; Hao B ; Li J ; Chen Y ; Hou X ; Chen L ; Li H Oncotarget 2017[Jun]; 8 (24 ): 39143-39153 PMID28388576 show ga T-cell-originated protein kinase (TOPK) is highly and frequently expressed in various cancer tissues and plays an indispensable role in the mitosis of cancer cells, and therefore, it is an important target for drug treatment of tumor. Ilaprazole was identified to be a potent TOPK inhibitor. The data indicated that ilaprazole inhibited TOPK activities with high affinity and selectivity. In vitro studies showed that ilaprazole inhibited TOPK activities in HCT116, ES-2, A549, SW1990 cancer cells. Moreover, knockdown of TOPK in these cells decreased their sensitivities to ilaprazole. Results of an in vivo study demonstrated that gavage of ilaprazole in HCT116 colon tumor-bearing mice effectively suppressed cancer growth. The TOPK downstream signaling molecule phospho-histone H3 in tumor tissues was also decreased after ilaprazole treatment. Our results suggested that ilaprazole inhibited the cancer growth by targeting TOPK both in vitro and in vivo. |2-Pyridinylmethylsulfinylbenzimidazoles/*pharmacology [MESH] |Animals [MESH] |Apoptosis/drug effects [MESH] |Biomarkers, Tumor/*metabolism [MESH] |Cell Proliferation/drug effects [MESH] |Colonic Neoplasms/*drug therapy/metabolism/pathology [MESH] |Gene Expression Regulation, Enzymologic/*drug effects [MESH] |Gene Expression Regulation, Neoplastic/*drug effects [MESH] |Humans [MESH] |Mice [MESH] |Mice, SCID [MESH] |Mitogen-Activated Protein Kinase Kinases/*antagonists & inhibitors/metabolism [MESH] |Phosphorylation/drug effects [MESH] |Proton Pump Inhibitors/*pharmacology [MESH] |Tumor Cells, Cultured [MESH]Proton pump inhibitor ilaprazole suppresses cancer growth by targeting(epmc).pdf DeepDyve Pubget Overpricing