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10.18632/oncotarget.16608 http://scihub22266oqcxt.onion/10.18632/oncotarget.16608 C5503600!5503600 !28388575     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28388575 &cmd=llinks): Failed to open stream: HTTP request failed! 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Cofilin 1 induces the epithelial-mesenchymal transition of gastric cancer cells by promoting cytoskeletal rearrangement |pdf=|usr=}}{{28388575 }} gab.com Text Cofilin 1 induces the epithelial-mesenchymal transition of gastric cancer cells by promoting cytoskeletal rearrangement JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28388575 #FOAvip Epithelial-mesenchymal transition (EMT) is an important biological process whereby malignant tumor cells obtain the ability to migrate, invade, resist apoptosis and degrade the extracellular matrix. We found that Cofilin1 (CFL1) expression was elevated in clinical gastric cancer specimens and correlated with biomarkers of EMT in BGC-823 gastric cancer cells. BGC-823 cells exhibited EMT phenotypes and increased metastatic ability when induced by TGF-?1. By contrast, BGC-823 cells transfected with Lv-siRNA-CFL1 did not exhibit EMT phenotypes under the same inducing conditions. As CFL1 expression increased, EMT cell filopodia stretched out. In addition, the ultrastructures observed using transmission electron microscopy indicated that silencing of CFL1 markedly inhibited depolymerization of fibrous actin and cytoskeletal reorganization during EMT. Similar results were obtained in vivo. These findings demonstrate that CFL1 induces EMT by promoting cytoskeletal rearrangement. Our results may provide the basis for developing new anticancer drugs to inhibit CFL1. Twit Text FOAVip Cofilin 1 induces the epithelial-mesenchymal transition of gastric cancer cells by promoting cytoskeletal rearrangement ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28388575 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28388575 #FOAvip English Wikipedia <ref>{{Cite pmid|28388575 }}</ref> Cofilin 1 induces the epithelial-mesenchymal transition of gastric cancer cells by promoting cytoskeletal rearrangement #MMPMID28388575 Wang H ; Tao L ; Jin F ; Gu H ; Dai X ; Ni T ; Feng J ; Ding Y ; Xiao W ; Qian Y ; Liu Y Oncotarget 2017[Jun]; 8 (24 ): 39131-39142 PMID28388575 show ga Epithelial-mesenchymal transition (EMT) is an important biological process whereby malignant tumor cells obtain the ability to migrate, invade, resist apoptosis and degrade the extracellular matrix. We found that Cofilin1 (CFL1) expression was elevated in clinical gastric cancer specimens and correlated with biomarkers of EMT in BGC-823 gastric cancer cells. BGC-823 cells exhibited EMT phenotypes and increased metastatic ability when induced by TGF-?1. By contrast, BGC-823 cells transfected with Lv-siRNA-CFL1 did not exhibit EMT phenotypes under the same inducing conditions. As CFL1 expression increased, EMT cell filopodia stretched out. In addition, the ultrastructures observed using transmission electron microscopy indicated that silencing of CFL1 markedly inhibited depolymerization of fibrous actin and cytoskeletal reorganization during EMT. Similar results were obtained in vivo. These findings demonstrate that CFL1 induces EMT by promoting cytoskeletal rearrangement. Our results may provide the basis for developing new anticancer drugs to inhibit CFL1. |*Epithelial-Mesenchymal Transition [MESH] |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Animals [MESH] |Apoptosis [MESH] |Biomarkers, Tumor/*metabolism [MESH] |Case-Control Studies [MESH] |Cell Proliferation [MESH] |Cofilin 1/*metabolism [MESH] |Cytoskeleton/metabolism/*pathology [MESH] |Female [MESH] |Gastric Mucosa/metabolism [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Male [MESH] |Mice [MESH] |Mice, Nude [MESH] |Middle Aged [MESH] |Prognosis [MESH] |Signal Transduction [MESH] |Stomach Neoplasms/metabolism/*pathology [MESH] |Stomach/*pathology [MESH] |Transforming Growth Factor beta1 [MESH] |Tumor Cells, Cultured [MESH]Cofilin 1 induces the epithelial-mesenchymal transition of gastric can(epmc).pdf DeepDyve Pubget Overpricing