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10.18632/oncotarget.16587 http://scihub22266oqcxt.onion/10.18632/oncotarget.16587 C5503594!5503594 !28388562     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28388562 &cmd=llinks): Failed to open stream: HTTP request failed! 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CBX7 negatively regulates migration and invasion in glioma via Wnt/?-catenin pathway inactivation |pdf=|usr=}}{{28388562 }} gab.com Text CBX7 negatively regulates migration and invasion in glioma via Wnt/ -catenin pathway inactivation JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28388562 #FOAvip CBX7, a member of the Polycomb-group proteins, plays a significant role in normal and cancerous tissues and has been defined as a tumor suppressor in thyroid, breast and pancreatic cancers. However, its function in glioma remains undefined. CBX7 expression is decreased in glioma, especially in higher grade cases, according to data in the CGGA, GSE16001 and TCGA databases. Further experimental evidence has shown that exogenous CBX7 overexpression induced apoptosis and inhibited cell proliferation, colony formation and migration of glioma cells. In this study, we show that the invasive ability of glioma cells was decreased following CBX7 overexpression and CBX7 overexpression was associated with Wnt/?-catenin pathway inhibition, which also decreased downstream expression of ZEB1, a core epithelial-to-mesenchymal transition factor. This reduction in Wnt signaling is controlled by DKK1, a specific Wnt/?-catenin inhibitor. CBX7 enhances DKK1 expression by binding the DKK1 promoter, as shown in Luciferase reporter assays. Our data confirm that CBX7 inhibits EMT and invasion in glioma, which is manifested by influencing the expression of MMP2, MMP9, E-cadherin, N-cadherin and Vimentin in LN229, T98G cells and primary glioma cells (PGC). Furthermore, as a tumor suppressor, CBX7 expression is pivotal to reduce tumor invasion and evaluate prognosis. Twit Text FOAVip CBX7 negatively regulates migration and invasion in glioma via Wnt/ -catenin pathway inactivation ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28388562 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28388562 #FOAvip English Wikipedia <ref>{{Cite pmid|28388562 }}</ref> CBX7 negatively regulates migration and invasion in glioma via Wnt/?-catenin pathway inactivation #MMPMID28388562 Bao Z ; Xu X ; Liu Y ; Chao H ; Lin C ; Li Z ; You Y ; Liu N ; Ji J Oncotarget 2017[Jun]; 8 (24 ): 39048-39063 PMID28388562 show ga CBX7, a member of the Polycomb-group proteins, plays a significant role in normal and cancerous tissues and has been defined as a tumor suppressor in thyroid, breast and pancreatic cancers. However, its function in glioma remains undefined. CBX7 expression is decreased in glioma, especially in higher grade cases, according to data in the CGGA, GSE16001 and TCGA databases. Further experimental evidence has shown that exogenous CBX7 overexpression induced apoptosis and inhibited cell proliferation, colony formation and migration of glioma cells. In this study, we show that the invasive ability of glioma cells was decreased following CBX7 overexpression and CBX7 overexpression was associated with Wnt/?-catenin pathway inhibition, which also decreased downstream expression of ZEB1, a core epithelial-to-mesenchymal transition factor. This reduction in Wnt signaling is controlled by DKK1, a specific Wnt/?-catenin inhibitor. CBX7 enhances DKK1 expression by binding the DKK1 promoter, as shown in Luciferase reporter assays. Our data confirm that CBX7 inhibits EMT and invasion in glioma, which is manifested by influencing the expression of MMP2, MMP9, E-cadherin, N-cadherin and Vimentin in LN229, T98G cells and primary glioma cells (PGC). Furthermore, as a tumor suppressor, CBX7 expression is pivotal to reduce tumor invasion and evaluate prognosis. |*Cell Movement/physiology [MESH] |Animals [MESH] |Brain Neoplasms/*pathology [MESH] |Cell Line, Tumor [MESH] |Epithelial-Mesenchymal Transition/physiology [MESH] |Gene Expression Regulation, Neoplastic/physiology [MESH] |Glioma/*pathology [MESH] |Heterografts [MESH] |Humans [MESH] |Mice [MESH] |Mice, Nude [MESH] |Neoplasm Invasiveness/pathology [MESH] |Polycomb Repressive Complex 1/*metabolism [MESH]CBX7 negatively regulates migration and invasion in glioma via Wnt/?-c(epmc).pdf DeepDyve Pubget Overpricing