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10.18632/oncotarget.16170

http://scihub22266oqcxt.onion/10.18632/oncotarget.16170
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C5503553!5503553!28423736
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suck abstract from ncbi


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pmid28423736      Oncotarget 2017 ; 8 (24): 38554-67
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  • Laminarin promotes anti-cancer immunity by the maturation of dendritic cells #MMPMID28423736
  • Song K; Xu L; Zhang W; Cai Y; Jang B; Oh J; Jin JO
  • Oncotarget 2017[Jun]; 8 (24): 38554-67 PMID28423736show ga
  • This research evaluates the effects of laminarin on the maturation of dendritic cells and on the in vivo activation of anti-cancer immunity. In vivo treatment of C56BL/6 mice with laminarin increased the expression levels of co-stimulatory molecules and the production of pro-inflammatory cytokines in spleen dendritic cells. Laminarin enhanced ovalbumin antigen presentation in spleen dendritic cells and promoted the proliferation of OT-I and OT-II T cells. Laminarin also induced the maturation of dendritic cells in tumor-draining lymph nodes and protected interferon-? and tumor necrosis factor-? and proliferation of OT-I and OT-II T cells in tumors. The combination treatment of laminarin and ovalbumin inhibited B16-ovallbumin melanoma tumor growth and its liver metastasis by antigen-specific immune activation, including cytotoxic T lymphocyte activation and interferon-? production. Thus, these data demonstrated the potential of laminarin as a new and useful immune stimulatory molecule for use in cancer immunotherapy.
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