Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1126/science.1242463 http://scihub22266oqcxt.onion/10.1126/science.1242463 C5502466!5502466!24136355     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2013 ; 342 (6159): 744-7 Nephropedia Template TP {{tp|p=24136355|t=2013. Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription |pdf=|usr=}}{{24136355}} gab.com Text Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=24136355 #FOAvip DNA sequence variation has been associated with quantitative changes in molecular phenotypes such as gene expression, but its impact on chromatin states is poorly characterized. To understand the interplay between chromatin and genetic control of gene regulation we quantified allelic variability in transcription factor binding, histone modifications, and gene expression within humans. We found abundant allelic specificity in chromatin and extensive local, short-, and long-range allelic coordination among the studied molecular phenotypes. We observed genetic influence on most of these phenotypes, with histone modifications exhibiting strong context-dependent behavior. Our results implicate transcription factors as primary mediators of sequence-specific regulation of gene expression programs, with histone modifications frequently reflecting the primary regulatory event. Twit Text FOAVip Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription ????Science http://www.kidney.de/pget.php?&tw=1&pmid=24136355 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24136355 #FOAvip English Wikipedia <ref>{{Cite pmid|24136355}}</ref> Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription #MMPMID24136355 Kilpinen H; Waszak SM; Gschwind AR; Raghav SK; Witwicki RM; Orioli A; Migliavacca E; Wiederkehr M; Gutierrez-Arcelus M; Panousis N; Yurovsky A; Lappalainen T; Romano-Palumbo L; Planchon A; Bielser D; Bryois J; Padioleau I; Udin G; Thurnheer S; Hacker D; Core LJ; Lis JT; Hernandez N; Reymond A; Deplancke B; Dermitzakis ET Science 2013[Nov]; 342 (6159): 744-7 PMID24136355show ga DNA sequence variation has been associated with quantitative changes in molecular phenotypes such as gene expression, but its impact on chromatin states is poorly characterized. To understand the interplay between chromatin and genetic control of gene regulation we quantified allelic variability in transcription factor binding, histone modifications, and gene expression within humans. We found abundant allelic specificity in chromatin and extensive local, short-, and long-range allelic coordination among the studied molecular phenotypes. We observed genetic influence on most of these phenotypes, with histone modifications exhibiting strong context-dependent behavior. Our results implicate transcription factors as primary mediators of sequence-specific regulation of gene expression programs, with histone modifications frequently reflecting the primary regulatory event. äCoordinated effects of sequence variation on DNA binding, chromatin st(epmc).pdf DeepDyve Pubget Overpricing