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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Exp+Med 2017 ; 214 (7): 2121-38 Nephropedia Template TP
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Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease #MMPMID28566277
Uderhardt S; Ackermann JA; Fillep T; Hammond VJ; Willeit J; Santer P; Mayr M; Biburger M; Miller M; Zellner KR; Stark K; Zarbock A; Rossaint J; Schubert I; Mielenz D; Dietel B; Raaz-Schrauder D; Ay C; Gremmel T; Thaler J; Heim C; Herrmann M; Collins PW; Schabbauer G; Mackman N; Voehringer D; Nadler JL; Lee JJ; Massberg S; Rauh M; Kiechl S; Schett G; O?Donnell VB; Krönke G
J Exp Med 2017[Jul]; 214 (7): 2121-38 PMID28566277show ga
Uderhardt et al. show that eosinophils accumulate in freshly formed thrombi, where they provide a procoagulant surface that is rich in oxidized phospholipids and allows assembly and activation of plasmatic coagulation factors. This mechanism stabilizes the thrombus and enables hemostasis but also contributes to thrombotic disease.