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10.1084/jem.20161070 http://scihub22266oqcxt.onion/10.1084/jem.20161070 C5502424!5502424 !28566277     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28566277 &cmd=llinks): Failed to open stream: HTTP request failed! 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Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease |pdf=|usr=}}{{28566277 }} gab.com Text Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=28566277 #FOAvip Blood coagulation is essential for physiological hemostasis but simultaneously contributes to thrombotic disease. However, molecular and cellular events controlling initiation and propagation of coagulation are still incompletely understood. In this study, we demonstrate an unexpected role of eosinophils during plasmatic coagulation, hemostasis, and thrombosis. Using a large-scale epidemiological approach, we identified eosinophil cationic protein as an independent and predictive risk factor for thrombotic events in humans. Concurrent experiments showed that eosinophils contributed to intravascular thrombosis by exhibiting a strong endogenous thrombin-generation capacity that relied on the enzymatic generation and active provision of a procoagulant phospholipid surface enriched in 12/15-lipoxygenase-derived hydroxyeicosatetraenoic acid-phosphatidylethanolamines. Our findings reveal a previously unrecognized role of eosinophils and enzymatic lipid oxidation as regulatory elements that facilitate both hemostasis and thrombosis in response to vascular injury, thus identifying promising new targets for the treatment of thrombotic disease. Twit Text FOAVip Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=28566277 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28566277 #FOAvip English Wikipedia <ref>{{Cite pmid|28566277 }}</ref> Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease #MMPMID28566277 Uderhardt S ; Ackermann JA ; Fillep T ; Hammond VJ ; Willeit J ; Santer P ; Mayr M ; Biburger M ; Miller M ; Zellner KR ; Stark K ; Zarbock A ; Rossaint J ; Schubert I ; Mielenz D ; Dietel B ; Raaz-Schrauder D ; Ay C ; Gremmel T ; Thaler J ; Heim C ; Herrmann M ; Collins PW ; Schabbauer G ; Mackman N ; Voehringer D ; Nadler JL ; Lee JJ ; Massberg S ; Rauh M ; Kiechl S ; Schett G ; O'Donnell VB ; Krönke G J Exp Med 2017[Jul]; 214 (7 ): 2121-2138 PMID28566277 show ga Blood coagulation is essential for physiological hemostasis but simultaneously contributes to thrombotic disease. However, molecular and cellular events controlling initiation and propagation of coagulation are still incompletely understood. In this study, we demonstrate an unexpected role of eosinophils during plasmatic coagulation, hemostasis, and thrombosis. Using a large-scale epidemiological approach, we identified eosinophil cationic protein as an independent and predictive risk factor for thrombotic events in humans. Concurrent experiments showed that eosinophils contributed to intravascular thrombosis by exhibiting a strong endogenous thrombin-generation capacity that relied on the enzymatic generation and active provision of a procoagulant phospholipid surface enriched in 12/15-lipoxygenase-derived hydroxyeicosatetraenoic acid-phosphatidylethanolamines. Our findings reveal a previously unrecognized role of eosinophils and enzymatic lipid oxidation as regulatory elements that facilitate both hemostasis and thrombosis in response to vascular injury, thus identifying promising new targets for the treatment of thrombotic disease. |*Blood Coagulation [MESH] |*Hemostasis [MESH] |Adult [MESH] |Aged [MESH] |Animals [MESH] |Arachidonate 12-Lipoxygenase/genetics/*metabolism [MESH] |Arachidonate 15-Lipoxygenase/genetics/*metabolism [MESH] |Atherosclerosis/diagnosis/metabolism [MESH] |Blotting, Western [MESH] |Cells, Cultured [MESH] |Eosinophil Cationic Protein/metabolism [MESH] |Eosinophils/*metabolism [MESH] |Humans [MESH] |Hydroxyeicosatetraenoic Acids/metabolism [MESH] |Lipids/*analysis [MESH] |Logistic Models [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Middle Aged [MESH] |Oxidation-Reduction [MESH] |Phosphatidylethanolamines/metabolism [MESH] |Prospective Studies [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |Risk Factors [MESH] |Thrombin/metabolism [MESH]Enzymatic lipid oxidation by eosinophils propagates coagulation, hemos(epmc).pdf DeepDyve Pubget Overpricing