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10.1126/science.aak9748 http://scihub22266oqcxt.onion/10.1126/science.aak9748 C5502115!5502115!28280205     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2017 ; 355 (6329): 1072-6 Nephropedia Template TP {{tp|p=28280205|t=2017. Molecular and neural basis of contagious itch behavior in mice |pdf=|usr=}}{{28280205}} gab.com Text Molecular and neural basis of contagious itch behavior in mice JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=28280205 #FOAvip Socially contagious itch is ubiquitous in human society, but whether it exists in rodents is unclear. Using a behavioral paradigm that does not entail prior training or reward, we found that mice scratched after observing a conspecific scratching. Molecular mapping showed increased neuronal activity in the suprachiasmatic nucleus (SCN) of the hypothalamus of mice that displayed contagious scratching. Ablation of gastrin-releasing peptide receptor (GRPR) or GRPR neurons in the SCN abolished contagious scratching behavior, which was recapitulated by chemogenetic inhibition of SCN GRP neurons. Activation of SCN GRP/GRPR neurons evoked scratching behavior. These data demonstrate that GRP-GRPR signaling is necessary and sufficient for transmitting contagious itch information in the SCN. The findings may have implications for our understanding of neural circuits that control socially contagious behaviors. Twit Text FOAVip Molecular and neural basis of contagious itch behavior in mice ????Science http://www.kidney.de/pget.php?&tw=1&pmid=28280205 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28280205 #FOAvip English Wikipedia <ref>{{Cite pmid|28280205}}</ref> Molecular and neural basis of contagious itch behavior in mice #MMPMID28280205 Yu YQ; Barry DM; Hao Y; Liu XT; Chen ZF Science 2017[Mar]; 355 (6329): 1072-6 PMID28280205show ga Socially contagious itch is ubiquitous in human society, but whether it exists in rodents is unclear. Using a behavioral paradigm that does not entail prior training or reward, we found that mice scratched after observing a conspecific scratching. Molecular mapping showed increased neuronal activity in the suprachiasmatic nucleus (SCN) of the hypothalamus of mice that displayed contagious scratching. Ablation of gastrin-releasing peptide receptor (GRPR) or GRPR neurons in the SCN abolished contagious scratching behavior, which was recapitulated by chemogenetic inhibition of SCN GRP neurons. Activation of SCN GRP/GRPR neurons evoked scratching behavior. These data demonstrate that GRP-GRPR signaling is necessary and sufficient for transmitting contagious itch information in the SCN. The findings may have implications for our understanding of neural circuits that control socially contagious behaviors. äMolecular and neural basis of contagious itch behavior in mice (epmc).pdf DeepDyve Pubget Overpricing