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10.1111/ajt.13728 http://scihub22266oqcxt.onion/10.1111/ajt.13728 C5501990!5501990 !26990570     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26990570 &cmd=llinks): Failed to open stream: HTTP request failed! 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Gene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms That Correlate With Worse Long-Term Outcomes |pdf=|usr=}}{{26990570 }} gab.com Text Gene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms That Correlate With Worse Long-Term Outcomes JO: Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=26990570 #FOAvip Interstitial fibrosis and tubular atrophy (IFTA) is found in approximately 25% of 1-year biopsies posttransplant. It is known that IFTA correlates with decreased graft survival when histological evidence of inflammation is present. Identifying the mechanistic etiology of IFTA is important to understanding why long-term graft survival has not changed as expected despite improved immunosuppression and dramatically reduced rates of clinical acute rejection (AR) (Services UDoHaH. http://www.ustransplant.org/annual_reports/current/509a_ki.htm). Gene expression profiles of 234 graft biopsy samples were obtained with matching clinical and outcome data. Eighty-one IFTA biopsies were divided into subphenotypes by degree of histological inflammation: IFTA with AR, IFTA with inflammation, and IFTA without inflammation. Samples with AR (n = 54) and normally functioning transplants (TX; n = 99) were used in comparisons. A novel analysis using gene coexpression networks revealed that all IFTA phenotypes were strongly enriched for dysregulated gene pathways and these were shared with the biopsy profiles of AR, including IFTA samples without histological evidence of inflammation. Thus, by molecular profiling we demonstrate that most IFTA samples have ongoing immune-mediated injury or chronic rejection that is more sensitively detected by gene expression profiling. These molecular biopsy profiles correlated with future graft loss in IFTA samples without inflammation. Twit Text FOAVip Gene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms That Correlate With Worse Long-Term Outcomes ????Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=26990570 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26990570 #FOAvip English Wikipedia <ref>{{Cite pmid|26990570 }}</ref> Gene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms That Correlate With Worse Long-Term Outcomes #MMPMID26990570 Modena BD ; Kurian SM ; Gaber LW ; Waalen J ; Su AI ; Gelbart T ; Mondala TS ; Head SR ; Papp S ; Heilman R ; Friedewald JJ ; Flechner SM ; Marsh CL ; Sung RS ; Shidban H ; Chan L ; Abecassis MM ; Salomon DR Am J Transplant 2016[Jul]; 16 (7 ): 1982-98 PMID26990570 show ga Interstitial fibrosis and tubular atrophy (IFTA) is found in approximately 25% of 1-year biopsies posttransplant. It is known that IFTA correlates with decreased graft survival when histological evidence of inflammation is present. Identifying the mechanistic etiology of IFTA is important to understanding why long-term graft survival has not changed as expected despite improved immunosuppression and dramatically reduced rates of clinical acute rejection (AR) (Services UDoHaH. http://www.ustransplant.org/annual_reports/current/509a_ki.htm). Gene expression profiles of 234 graft biopsy samples were obtained with matching clinical and outcome data. Eighty-one IFTA biopsies were divided into subphenotypes by degree of histological inflammation: IFTA with AR, IFTA with inflammation, and IFTA without inflammation. Samples with AR (n = 54) and normally functioning transplants (TX; n = 99) were used in comparisons. A novel analysis using gene coexpression networks revealed that all IFTA phenotypes were strongly enriched for dysregulated gene pathways and these were shared with the biopsy profiles of AR, including IFTA samples without histological evidence of inflammation. Thus, by molecular profiling we demonstrate that most IFTA samples have ongoing immune-mediated injury or chronic rejection that is more sensitively detected by gene expression profiling. These molecular biopsy profiles correlated with future graft loss in IFTA samples without inflammation. |*Gene Expression Profiling [MESH] |Atrophy/genetics/*mortality [MESH] |Fibrosis/genetics/*mortality [MESH] |Glomerular Filtration Rate [MESH] |Graft Rejection/genetics/*mortality [MESH] |Graft Survival [MESH] |Humans [MESH] |Kidney Failure, Chronic/genetics/surgery [MESH] |Kidney Function Tests [MESH] |Kidney Transplantation/*methods [MESH] |Kidney Tubules/metabolism/*pathology [MESH] |Nephritis, Interstitial/genetics/*mortality [MESH] |Prognosis [MESH] |Risk Factors [MESH]Gene Expression in Biopsies of Acute Rejection and Interstitial Fibros(epmc).pdf DeepDyve Pubget Overpricing