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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Gastroenterology
2017 ; 152
(6
): 1297-1309
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Hepatitis B Reactivation Associated With Immune Suppressive and Biological
Modifier Therapies: Current Concepts, Management Strategies, and Future
Directions
#MMPMID28219691
Loomba R
; Liang TJ
Gastroenterology
2017[May]; 152
(6
): 1297-1309
PMID28219691
show ga
Hepatitis B reactivation associated with immune-suppressive and biological
therapies is emerging to be an important cause of morbidity and mortality in
patients with current or prior exposure to hepatitis B virus (HBV) infection. The
population at risk for HBV reactivation includes those who either currently are
infected with HBV or have had past exposure to HBV. Because curative and
eradicative therapy for HBV is not currently available, there is a large
reservoir of individuals at risk for HBV reactivation in the general population.
HBV reactivation with its potential consequences is particularly a concern when
these people are exposed to either cancer chemotherapy, immunosuppressive or
biologic therapies for the management of rheumatologic conditions, malignancies,
inflammatory bowel disease, dermatologic conditions, or solid-organ or bone
marrow transplantation. With the advent of newer and emerging forms of targeted
biologic therapies, it has become important to understand the mechanisms whereby
certain therapies are more prone to HBV reactivation. This review provides a
comprehensive update on the current concepts, risk factors, molecular mechanisms,
prevention, and management of hepatitis B reactivation. In addition, we provide
recommendations for future research in this area.
|*Virus Activation
[MESH]
|Antiviral Agents/*therapeutic use
[MESH]
|Biological Products/*adverse effects
[MESH]
|Hepatitis B virus/*physiology
[MESH]
|Hepatitis B, Chronic/epidemiology/*prevention & control
[MESH]