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10.1161/HYPERTENSIONAHA.117.09283 http://scihub22266oqcxt.onion/10.1161/HYPERTENSIONAHA.117.09283 C5501939!5501939!28533331     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hypertension 2017 ; 70 (1): 119-28 Nephropedia Template TP {{tp|p=28533331|t=2017. CHRONIC STIMULATION OF RENIN CELLS LEADS TO VASCULAR PATHOLOGY |pdf=|usr=}}{{28533331}} gab.com Text CHRONIC STIMULATION OF RENIN CELLS LEADS TO VASCULAR PATHOLOGY JO: Hypertension http://www.kidney.de/pget.php?&tw=1&pmid=28533331 #FOAvip Experimental or spontaneous genomic mutations of the renin-angiotensin system or its pharmacological inhibition in early life leads to renal abnormalities including poorly developed renal medulla, papillary atrophy, hydronephrosis, inability to concentrate the urine, polyuria, polydipsia, renal failure and anemia. At the core of such complex phenotype is the presence of unique vascular abnormalities: the renal arterioles do not branch or elongate properly and they have disorganized, concentric hypertrophy. This lesion has been puzzling because it is often found in hypertensive individuals whereas mutant or pharmacologically inhibited animals are hypotensive. Remarkably, when renin cells are ablated with diphtheria toxin, the vascular hypertrophy does not occur suggesting that renin cells per se may contribute to the vascular disease. To test this hypothesis, on a Ren1c?/? background, we generated mutant mice with reporter expression (Ren1c?/?;Ren1c-Cre;R26R.mTmG; and Ren1c?/?;Ren1c-Cre;R26R.LacZ ) to trace the fate of reninnull cells. To assess whether reninnull cells maintain their renin promoter active, we used Ren1c?/?;Ren1c-YFP mice which transcribe YFP directed by the renin promoter. We also followed the expression of Akr1b7 and miR-330-5p, markers of cells programmed for the renin phenotype. Contrary to what we expected, reninnull cells did not die or disappear. Instead, they survived, increased in number along the renal arterial tree, and maintained an active molecular memory of the myo-epitheliod renin phenotype. Further, null cells of the renin lineage occupied the walls of the arteries and arterioles in a chaotic, directionless pattern directly contributing to the concentric arterial hypertrophy. Twit Text FOAVip CHRONIC STIMULATION OF RENIN CELLS LEADS TO VASCULAR PATHOLOGY ????Hypertension http://www.kidney.de/pget.php?&tw=1&pmid=28533331 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28533331 #FOAvip English Wikipedia <ref>{{Cite pmid|28533331}}</ref> CHRONIC STIMULATION OF RENIN CELLS LEADS TO VASCULAR PATHOLOGY #MMPMID28533331 Oka M; Medrano S; Sequeira-López MLS; Gómez RA Hypertension 2017[Jul]; 70 (1): 119-28 PMID28533331show ga Experimental or spontaneous genomic mutations of the renin-angiotensin system or its pharmacological inhibition in early life leads to renal abnormalities including poorly developed renal medulla, papillary atrophy, hydronephrosis, inability to concentrate the urine, polyuria, polydipsia, renal failure and anemia. At the core of such complex phenotype is the presence of unique vascular abnormalities: the renal arterioles do not branch or elongate properly and they have disorganized, concentric hypertrophy. This lesion has been puzzling because it is often found in hypertensive individuals whereas mutant or pharmacologically inhibited animals are hypotensive. Remarkably, when renin cells are ablated with diphtheria toxin, the vascular hypertrophy does not occur suggesting that renin cells per se may contribute to the vascular disease. To test this hypothesis, on a Ren1c?/? background, we generated mutant mice with reporter expression (Ren1c?/?;Ren1c-Cre;R26R.mTmG; and Ren1c?/?;Ren1c-Cre;R26R.LacZ ) to trace the fate of reninnull cells. To assess whether reninnull cells maintain their renin promoter active, we used Ren1c?/?;Ren1c-YFP mice which transcribe YFP directed by the renin promoter. We also followed the expression of Akr1b7 and miR-330-5p, markers of cells programmed for the renin phenotype. Contrary to what we expected, reninnull cells did not die or disappear. Instead, they survived, increased in number along the renal arterial tree, and maintained an active molecular memory of the myo-epitheliod renin phenotype. Further, null cells of the renin lineage occupied the walls of the arteries and arterioles in a chaotic, directionless pattern directly contributing to the concentric arterial hypertrophy. äCHRONIC STIMULATION OF RENIN CELLS LEADS TO VASCULAR PATHOLOGY (epmc).pdf DeepDyve Pubget Overpricing