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10.1038/s41598-017-05280-6 http://scihub22266oqcxt.onion/10.1038/s41598-017-05280-6 C5501852!5501852 !28687755     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28687755 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 4915 Nephropedia Template TP {{tp|p=28687755 |t=2017. The integrated pathway of TGF?/Snail with TNF?/NF?B may facilitate the tumor-stroma interaction in the EMT process and colorectal cancer prognosis |pdf=|usr=}}{{28687755 }} gab.com Text The integrated pathway of TGF /Snail with TNF /NF B may facilitate the tumor-stroma interaction in the EMT process and colorectal cancer prognosis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28687755 #FOAvip Substantial evidence has shown that epithelial-mesenchymal transition (EMT) plays critical roles in colorectal cancer (CRC) development and prognosis. To uncover the pivotal regulators that function in the cooperative interactions between cancer cells and their microenvironment and consequently affect the EMT process, we carried out a systematic analysis and evaluated prognosis in CRC specimens. Tumor buds and their surrounding stroma were captured using laser microdissection. We used gene expression profiling, bioinformatics analysis and regulatory network construction for molecular selection. The clinical significance of potential biomarkers was investigated. We identified potential EMT biomarkers, including BGN, MMP1, LGALS1, SERPINB5, and TM4SF4, all of which participated in the integrated pathway of TGF?/Snail with TNF?/NF?B. We also found that BGN, MMP1, LGALS1, SERPINB5 and TM4SF4 were related to CRC patient prognosis. Patients with higher expression of these individual potential biomarkers had poorer prognosis. Among the identified biomarkers, BGN and TM4SF4 are reported, for the first time, to probably be involved in the EMT process and to predict CRC prognosis. Our results strongly suggest that the integrated pathway of TGF?/Snail with TNF?/NF?B may be the principal axis that links cancer cells to their microenvironment during the EMT process and results in poor prognosis in CRC patients. Twit Text FOAVip The integrated pathway of TGF /Snail with TNF /NF B may facilitate the tumor-stroma interaction in the EMT process and colorectal cancer prognosis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28687755 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28687755 #FOAvip English Wikipedia <ref>{{Cite pmid|28687755 }}</ref> The integrated pathway of TGF?/Snail with TNF?/NF?B may facilitate the tumor-stroma interaction in the EMT process and colorectal cancer prognosis #MMPMID28687755 Li H ; Zhong A ; Li S ; Meng X ; Wang X ; Xu F ; Lai M Sci Rep 2017[Jul]; 7 (1 ): 4915 PMID28687755 show ga Substantial evidence has shown that epithelial-mesenchymal transition (EMT) plays critical roles in colorectal cancer (CRC) development and prognosis. To uncover the pivotal regulators that function in the cooperative interactions between cancer cells and their microenvironment and consequently affect the EMT process, we carried out a systematic analysis and evaluated prognosis in CRC specimens. Tumor buds and their surrounding stroma were captured using laser microdissection. We used gene expression profiling, bioinformatics analysis and regulatory network construction for molecular selection. The clinical significance of potential biomarkers was investigated. We identified potential EMT biomarkers, including BGN, MMP1, LGALS1, SERPINB5, and TM4SF4, all of which participated in the integrated pathway of TGF?/Snail with TNF?/NF?B. We also found that BGN, MMP1, LGALS1, SERPINB5 and TM4SF4 were related to CRC patient prognosis. Patients with higher expression of these individual potential biomarkers had poorer prognosis. Among the identified biomarkers, BGN and TM4SF4 are reported, for the first time, to probably be involved in the EMT process and to predict CRC prognosis. Our results strongly suggest that the integrated pathway of TGF?/Snail with TNF?/NF?B may be the principal axis that links cancer cells to their microenvironment during the EMT process and results in poor prognosis in CRC patients. |*Gene Expression Regulation, Neoplastic [MESH] |Biglycan/genetics/metabolism [MESH] |Biomarkers, Tumor/*genetics/metabolism [MESH] |Carcinogenesis/*genetics/metabolism/pathology [MESH] |Colorectal Neoplasms/*diagnosis/*genetics/mortality/pathology [MESH] |Epithelial-Mesenchymal Transition/*genetics [MESH] |Gene Expression Profiling [MESH] |Gene Regulatory Networks [MESH] |Humans [MESH] |Membrane Glycoproteins/genetics/metabolism [MESH] |NF-kappa B/genetics/metabolism [MESH] |Neoplasm Proteins/*genetics/metabolism [MESH] |Prognosis [MESH] |Signal Transduction [MESH] |Snail Family Transcription Factors/genetics/metabolism [MESH] |Survival Analysis [MESH] |Transforming Growth Factor beta1/genetics/metabolism [MESH] |Tumor Microenvironment [MESH]The integrated pathway of TGF?/Snail with TNF?/NF?B may facilitate the(epmc).pdf DeepDyve Pubget Overpricing