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2017 ; 7
(1
): 4852
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Blast-Induced Tinnitus and Elevated Central Auditory and Limbic Activity in Rats:
A Manganese-Enhanced MRI and Behavioral Study
#MMPMID28687812
Ouyang J
; Pace E
; Lepczyk L
; Kaufman M
; Zhang J
; Perrine SA
; Zhang J
Sci Rep
2017[Jul]; 7
(1
): 4852
PMID28687812
show ga
Blast-induced tinitus is the number one service-connected disability that
currently affects military personnel and veterans. To elucidate its underlying
mechanisms, we subjected 13 Sprague Dawley adult rats to unilateral 14?psi blast
exposure to induce tinnitus and measured auditory and limbic brain activity using
manganese-enhanced MRI (MEMRI). Tinnitus was evaluated with a gap detection
acoustic startle reflex paradigm, while hearing status was assessed with prepulse
inhibition (PPI) and auditory brainstem responses (?ABR??s). Both anxiety and
cognitive functioning were assessed using elevated plus maze and Morris water
maze, respectively. Five weeks after blast exposure, 8 of the 13 blasted rats
exhibited chronic tinnitus. While acoustic PPI remained intact and ABR thresholds
recovered, the ABR wave P1-N1 amplitude reduction persisted in all blast-exposed
rats. No differences in spatial cognition were observed, but blasted rats as a
whole exhibited increased anxiety. MEMRI data revealed a bilateral increase in
activity along the auditory pathway and in certain limbic regions of rats with
tinnitus compared to age-matched controls. Taken together, our data suggest that
while blast-induced tinnitus may play a role in auditory and limbic
hyperactivity, the non-auditory effects of blast and potential traumatic brain
injury may also exert an effect.
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