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2017 ; 12
(7
): e0180851
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Axial length changes in highly myopic eyes and influence of myopic macular
complications in Japanese adults
#MMPMID28686709
Ohsugi H
; Ikuno Y
; Shoujou T
; Oshima K
; Ohsugi E
; Tabuchi H
PLoS One
2017[]; 12
(7
): e0180851
PMID28686709
show ga
PURPOSE: To investigate changes of the axial length in normal eyes and highly
myopic eyes and influence of myopic macular complications in Japanese adults.
STUDY DESIGN: Retrospective longitudinal case series. METHODS: The changes in the
axial length of 316 eyes from 316 patients (mean age, 63.8 ± 9.0 years; range,
34-82; 240 females) examined using IOLMaster with a follow-up period of at least
1 year were studied. This study included 85 non-highly myopic eyes (|refractive
error| ? 5 diopters; 63 females; non-highly myopic group), 165 highly myopic eyes
(refractive error ? -6 diopters or axial length ? 26 mm; 124 females) without
macular complications (no complications group), 32 eyes (25 females) with myopic
traction maculopathy (MTM group), and 34 eyes (28 females) with myopic choroidal
neovascularization (CNV group). RESULTS: All groups showed a significant increase
in the axial length during the follow-up period (mean follow-up, 28.7 ± 16.8
months; range, 12-78) (P < 0.01). Changes in the axial length/year in the no
complications group (0.041 ± 0.05 mm) were significantly greater than those in
the non-highly myopic group (0.007 ± 0.02 mm) (P < 0.0001). Furthermore, changes
in the CNV group (0.081 ± 0.04 mm) were significantly greater than those in the
no complications (P < 0.0001) and MTM (0.040 ± 0.05 mm) (P = 0.0059) groups,
whereas no significant difference was found between the changes in the MTM and no
complications groups (P = 0.91). Multiple regression analyses indicated that CNV
eyes (P < 0.0001) and female patients' eyes (P = 0.04) showed greater changes in
the axial length/year. CONCLUSIONS: All groups showed an increase in the axial
length, which was greater for highly myopic eyes. In particular, CNV eyes showed
greater increases, indicating that larger changes in the axial length may require
careful follow-up.