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10.4049/jimmunol.1700406 http://scihub22266oqcxt.onion/10.4049/jimmunol.1700406 C5501482!5501482!28539428     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28539428.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol 2017 ; 199 (1): 33-8 Nephropedia Template TP {{tp|p=28539428|t=2017. Dual TCR? expression poses an autoimmune hazard by limiting Treg cell generation |pdf=|usr=}}{{28539428}} gab.com Text Dual TCR expression poses an autoimmune hazard by limiting Treg cell generation JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28539428 #FOAvip Despite accounting for 10?30% of the T cell population in mice and humans, the role of dual TCR-expressing T cells in immunity remains poorly understood. It has been hypothesized that dual TCR T cells pose an ?autoimmune hazard? by allowing self-reactive TCRs to escape thymic selection. We revisited this hypothesis using the NOD murine model of type 1 diabetes (T1D). We bred NOD mice hemizygous at both TCR? and ? (TCR?+/? ?+/?) loci, rendering them incapable of producing dual TCR T cells. We found that the lack of dual TCR? expression skewed the insulin-specific thymocyte population toward greater regulatory T (Treg) cell commitment, resulting in a more tolerogenic Treg to conventional T (Tconv) cell ratio and protection from diabetes. These data support a novel hypothesis by which dual TCR expression can promote autoimmunity by limiting agonist selection of self-reactive thymocytes into the Treg cell lineage. Twit Text FOAVip Dual TCR expression poses an autoimmune hazard by limiting Treg cell generation ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28539428 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28539428 #FOAvip English Wikipedia <ref>{{Cite pmid|28539428}}</ref> Dual TCR? expression poses an autoimmune hazard by limiting Treg cell generation #MMPMID28539428 Schuldt NJ; Auger JL; Spanier JA; Martinov T; Breed ER; Fife BT; Hogquist KA; Binstadt BA J Immunol 2017[Jul]; 199 (1): 33-8 PMID28539428show ga Despite accounting for 10?30% of the T cell population in mice and humans, the role of dual TCR-expressing T cells in immunity remains poorly understood. It has been hypothesized that dual TCR T cells pose an ?autoimmune hazard? by allowing self-reactive TCRs to escape thymic selection. We revisited this hypothesis using the NOD murine model of type 1 diabetes (T1D). We bred NOD mice hemizygous at both TCR? and ? (TCR?+/? ?+/?) loci, rendering them incapable of producing dual TCR T cells. We found that the lack of dual TCR? expression skewed the insulin-specific thymocyte population toward greater regulatory T (Treg) cell commitment, resulting in a more tolerogenic Treg to conventional T (Tconv) cell ratio and protection from diabetes. These data support a novel hypothesis by which dual TCR expression can promote autoimmunity by limiting agonist selection of self-reactive thymocytes into the Treg cell lineage. äDual TCR? expression poses an autoimmune hazard by limiting Treg cell (epmc).pdf DeepDyve Pubget Overpricing