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10.4049/jimmunol.1700406 http://scihub22266oqcxt.onion/10.4049/jimmunol.1700406 C5501482!5501482 !28539428     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28539428 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol 2017 ; 199 (1 ): 33-38 Nephropedia Template TP {{tp|p=28539428 |t=2017. Cutting Edge: Dual TCR? Expression Poses an Autoimmune Hazard by Limiting Regulatory T Cell Generation |pdf=|usr=}}{{28539428 }} gab.com Text Cutting Edge: Dual TCR Expression Poses an Autoimmune Hazard by Limiting Regulatory T Cell Generation JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28539428 #FOAvip Despite accounting for 10-30% of the T cell population in mice and humans, the role of dual TCR-expressing T cells in immunity remains poorly understood. It has been hypothesized that dual TCR T cells pose an autoimmune hazard by allowing self-reactive TCRs to escape thymic selection. We revisited this hypothesis using the NOD murine model of type 1 diabetes. We bred NOD mice hemizygous at both TCR? and ? (TCR?(+/-) ?(+/-)) loci, rendering them incapable of producing dual TCR T cells. We found that the lack of dual TCR? expression skewed the insulin-specific thymocyte population toward greater regulatory T (T(reg)) cell commitment, resulting in a more tolerogenic T(reg) to conventional T cell ratio and protection from diabetes. These data support a novel hypothesis by which dual TCR expression can promote autoimmunity by limiting agonist selection of self-reactive thymocytes into the T(reg) cell lineage. Twit Text FOAVip Cutting Edge: Dual TCR Expression Poses an Autoimmune Hazard by Limiting Regulatory T Cell Generation ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28539428 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28539428 #FOAvip English Wikipedia <ref>{{Cite pmid|28539428 }}</ref> Cutting Edge: Dual TCR? Expression Poses an Autoimmune Hazard by Limiting Regulatory T Cell Generation #MMPMID28539428 Schuldt NJ ; Auger JL ; Spanier JA ; Martinov T ; Breed ER ; Fife BT ; Hogquist KA ; Binstadt BA J Immunol 2017[Jul]; 199 (1 ): 33-38 PMID28539428 show ga Despite accounting for 10-30% of the T cell population in mice and humans, the role of dual TCR-expressing T cells in immunity remains poorly understood. It has been hypothesized that dual TCR T cells pose an autoimmune hazard by allowing self-reactive TCRs to escape thymic selection. We revisited this hypothesis using the NOD murine model of type 1 diabetes. We bred NOD mice hemizygous at both TCR? and ? (TCR?(+/-) ?(+/-)) loci, rendering them incapable of producing dual TCR T cells. We found that the lack of dual TCR? expression skewed the insulin-specific thymocyte population toward greater regulatory T (T(reg)) cell commitment, resulting in a more tolerogenic T(reg) to conventional T cell ratio and protection from diabetes. These data support a novel hypothesis by which dual TCR expression can promote autoimmunity by limiting agonist selection of self-reactive thymocytes into the T(reg) cell lineage. |*Autoimmunity [MESH] |Animals [MESH] |Diabetes Mellitus, Type 1/immunology [MESH] |Mice [MESH] |Mice, Inbred NOD [MESH] |Receptors, Antigen, T-Cell, alpha-beta/*genetics/*immunology [MESH] |T-Lymphocytes, Regulatory/*immunology/physiology [MESH]Cutting Edge: Dual TCR? Expression Poses an Autoimmune Hazard by Limit(epmc).pdf DeepDyve Pubget Overpricing